Understanding the fundamental chemical properties and synthesis routes of key intermediates is crucial for any chemist or procurement specialist. 2,3-Difluoronitrobenzene, identified by CAS number 6921-22-8, is a notable compound with distinct characteristics that make it valuable in various industrial applications, particularly in organic synthesis.

Chemical Identity and Properties

2,3-Difluoronitrobenzene, with the molecular formula C6H3F2NO2, possesses a molecular weight of 159.09 g/mol. It typically presents as a light yellow to yellow transparent liquid. The compound's structure features a benzene ring substituted with two fluorine atoms at the ortho and meta positions relative to each other, and a nitro group at the adjacent position. This specific arrangement dictates its reactivity and utility in subsequent chemical transformations. While the predicted boiling point is around 219.0 ± 20.0 °C, and density approximately 1.450 ± 0.06 g/cm³, these values are critical for process design and handling.

Synthesis Pathways for 2,3-Difluoronitrobenzene

A common and effective method for synthesizing 2,3-Difluoronitrobenzene involves the transformation of 2,3-Difluoroaniline. This process typically employs an oxidizing agent, such as hydrogen peroxide in combination with trifluoroacetic anhydride, often in a dichloromethane solvent. The reaction proceeds under controlled temperature conditions, usually starting at 0°C and gradually warming to room temperature overnight. Following the reaction, extraction with dichloromethane, drying over anhydrous sodium sulfate, filtration, and concentration under reduced pressure are standard work-up procedures. Purification, often achieved through flash column chromatography using hexane and ethyl acetate gradients, yields the desired 2,3-Difluoronitrobenzene. This synthesis route allows for efficient production, making it amenable to large-scale manufacturing by chemical suppliers.

For businesses looking to purchase 2,3-difluoronitrobenzene CAS 6921-22-8, understanding these synthesis methods helps in appreciating the product's origin and potential variations in purity. Working with a reliable 2,3-difluoronitrobenzene manufacturer in China ensures that these processes are optimized for consistent quality and yield.

Storage and Handling Considerations

Proper storage of 2,3-Difluoronitrobenzene is essential to maintain its integrity. It is recommended to store the compound sealed in a dry environment at room temperature. Its classification as an irritant (Xi) necessitates appropriate handling precautions, including the use of personal protective equipment such as gloves, eye protection, and respiratory protection if necessary. Adherence to safety guidelines, as outlined in the Safety Data Sheet (SDS), is paramount for safe laboratory and industrial use.

In summary, the chemical properties and synthesis of 2,3-Difluoronitrobenzene are well-documented, providing a solid foundation for its application. For those in need of this vital intermediate, sourcing from established manufacturers who can guarantee purity and adhere to safe handling practices is highly recommended.