Understanding the Chemical Properties and Uses of 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl Chloride
2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride (CAS 154445-78-0), often referred to as Pbf-Cl, is a specialized organosulfur compound with a unique bicyclic structure. Its molecular formula is C13H17ClO3S, and it typically presents as a blue solid with a melting point range of 69-71°C. The presence of the sulfonyl chloride functional group (-SO2Cl) makes it a highly reactive compound, susceptible to nucleophilic attack, and it is also noted as being moisture-sensitive. These chemical properties dictate its handling and storage, with recommendations often including storage at 2-8°C in dry conditions, preferably under an inert atmosphere like nitrogen. Its stability and reactivity profile make it an ideal reagent for specific synthetic transformations.
The primary utility of 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride lies in its role as a protecting group reagent in organic synthesis, particularly within peptide chemistry. It is used to introduce the Pbf protecting group onto the guanidine side chain of arginine residues. This protection is essential during complex peptide synthesis strategies, preventing unwanted side reactions and ensuring the integrity of the growing peptide chain. Following synthesis, the Pbf group can be cleaved effectively, typically with trifluoroacetic acid (TFA). Its reliability and efficiency have made it a standard tool for researchers in drug discovery, medicinal chemistry, and the synthesis of complex peptides with therapeutic potential.
For scientists and procurement managers seeking this compound, NINGBO INNO PHARMCHEM CO.,LTD. stands as a distinguished manufacturer and supplier in China. We ensure that our 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride is produced to exacting standards, providing the purity and consistency required for advanced research. By choosing us, you gain access to a dependable supply chain, competitive prices, and expert technical support. We are committed to facilitating your scientific endeavors by providing high-quality chemical intermediates. Inquire today to learn more about purchasing this vital reagent.
Perspectives & Insights
Bio Analyst 88
“These chemical properties dictate its handling and storage, with recommendations often including storage at 2-8°C in dry conditions, preferably under an inert atmosphere like nitrogen.”
Nano Seeker Pro
“Its stability and reactivity profile make it an ideal reagent for specific synthetic transformations.”
Data Reader 7
“The primary utility of 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl chloride lies in its role as a protecting group reagent in organic synthesis, particularly within peptide chemistry.”