Trifluoroacetic Acid-D, denoted by CAS number 599-00-8, is a specialized chemical compound that holds significant importance in various scientific and industrial applications. As a deuterated analog of trifluoroacetic acid, it inherits its parent compound's strong acidic nature while benefiting from the isotopic substitution, which renders it particularly useful in specific analytical and synthetic contexts. The high purity, typically ≥99.5% atom D, is a hallmark of this reagent, ensuring its effectiveness in demanding chemical processes.

Chemically, TFA-D is a colorless, transparent liquid. Its molecular formula is C2DF3O2, and it possesses a molecular weight of approximately 115.03 g/mol. The presence of fluorine atoms on the carbon adjacent to the carboxyl group significantly enhances its acidity compared to non-fluorinated carboxylic acids like acetic acid. This strong acidity is a key property exploited in numerous chemical reactions. For instance, it acts as a potent catalyst in esterifications, acylations, and serves as an effective reagent for the removal of protecting groups, such as the widely used Boc group in peptide synthesis.

The deuteration of TFA-D also makes it an ideal solvent for Nuclear Magnetic Resonance (NMR) spectroscopy. In NMR studies, the solvent's proton signal can interfere with the analysis of the analyte. By using a deuterated solvent like TFA-D, these interfering signals are minimized, allowing for clearer observation of the target molecule's spectrum. This is invaluable for researchers working with peptides, proteins, and other biomolecules where detailed structural information is required. Its use as a solvent is often complemented by its role as an ion-pairing agent in liquid chromatography-mass spectrometry (LC-MS) for the analysis of peptides and small proteins.

For laboratories requiring this specialized chemical, understanding where to buy Trifluoroacetic Acid-D is essential. A reliable Trifluoroacetic Acid-D supplier, ideally a direct Trifluoroacetic Acid-D manufacturer from regions like China, can provide the necessary quality assurance and competitive Trifluoroacetic Acid-D chemical pricing. When you source your deuterated trifluoroacetic acid from us, you are assured of a product that meets stringent purity standards, supporting your critical research and development activities.