In the realm of advanced chemical synthesis, catalysts are indispensable tools that enable complex transformations with precision and efficiency. Dichloro(o-isopropoxyphenylmethylene)ruthenium (CAS 301224-40-8) is a prime example of such a catalyst, renowned for its exceptional performance in olefin metathesis reactions. This article explores its key chemical properties and the wide array of applications that make it a sought-after reagent for researchers and industrial chemists alike.

At its core, dichloro(o-isopropoxyphenylmethylene)ruthenium is a ruthenium-based carbene complex. Its molecular formula, C31H38Cl2N2ORu, and molecular weight of approximately 626.62 g/mol, provide fundamental identifiers. Typically appearing as a green to very dark green solid, its physical form is a key characteristic noted by many suppliers. Its melting point, generally cited between 216-220 °C, indicates a stable solid under standard conditions. The stability of the compound is also mentioned as being hygroscopic, suggesting appropriate storage conditions of around 2-8°C are recommended to maintain its integrity and reactivity. Solubilities are typically noted as slight in common organic solvents like chloroform, dichloromethane, and methanol.

The true value of this catalyst, however, lies in its chemical reactivity. Often referred to as Hoveyda-Grubbs Catalyst 2nd Generation, it is a phosphine-free variant of Grubbs' second-generation catalyst. This structural feature contributes to its comparable reactivity but also offers advantages in initiation, often occurring more readily and at lower temperatures. This characteristic is particularly beneficial when dealing with sensitive substrates or when aiming for reactions that require precise control over initiation kinetics.

The primary application domain for dichloro(o-isopropoxyphenylmethylene)ruthenium is olefin metathesis. This powerful reaction allows for the rearrangement of carbon-carbon double bonds, enabling the synthesis of a vast array of organic molecules. Specifically, it is highly effective in:

  • Cross-Metathesis (CM): Reacting two different olefins to form new, cross-coupled olefins.
  • Ring-Closing Metathesis (RCM): Forming cyclic compounds from diene substrates, a crucial step in synthesizing many heterocyclic compounds and natural products.
  • Ring-Opening Metathesis (ROM): Breaking open cyclic olefins, often leading to linear polymers or functionalized acyclic molecules.

Furthermore, its efficacy extends to the metathesis of electron-deficient substrates and fluorinated olefins, which are often challenging for other catalysts. This capability makes it indispensable in the synthesis of specialized fluorinated compounds and complex pharmaceutical intermediates.

Its demonstrated utility in large-scale pharmaceutical applications underscores its industrial relevance. Researchers and manufacturers can buy this catalyst from reputable suppliers to streamline complex synthesis routes for drug discovery and production. The ability to achieve high yields and selectivity from a reliable manufacturer ensures that process development can proceed with confidence.

For B2B buyers seeking this catalyst, understanding its CAS number (301224-40-8) and common synonyms like 'Hoveyda-Grubbs Catalyst 2nd Generation' is essential for accurate product searches. Engaging with manufacturers and suppliers, particularly those based in China, can provide access to this advanced reagent at competitive prices. Always inquire about product specifications and recommended storage conditions to ensure optimal performance in your intended applications. The reliable availability of this catalyst from dedicated suppliers facilitates ongoing innovation in chemical research and industrial production.