Tert-Butylchlorodiphenylsilane (CAS 58479-61-1), an organosilicon compound with the molecular formula C16H19ClSi, is a highly valued chemical reagent renowned for its utility in organic synthesis and beyond. Possessing a unique molecular structure that balances steric bulk with reactive potential, it serves as a critical component in various chemical processes. This article delves into its key chemical properties and diverse applications, highlighting why it is a sought-after product for research and industrial use. As a leading manufacturer and supplier, we ensure the availability of high-quality Tert-Butylchlorodiphenylsilane to meet your needs.

Chemically, Tert-Butylchlorodiphenylsilane is characterized by a silicon atom bonded to a chlorine atom, a tert-butyl group, and two phenyl groups. This structure dictates its reactivity and physical properties. It typically appears as a clear, colorless to slightly yellow liquid, with a boiling point around 90-92°C at very low pressure (0.01 mmHg). Its density is approximately 1.057 g/mL at 25°C, and its refractive index is around 1.568. The compound is generally soluble in common organic solvents but reacts with moisture, making it a moisture-sensitive substance that requires careful handling and storage, typically under an inert atmosphere and at cool temperatures (2-8°C).

The reactivity of the Si-Cl bond is central to its function. This bond is susceptible to nucleophilic attack, which is the basis for its primary application as a silylating agent. In organic synthesis, it is widely used to introduce the tert-butyldiphenylsilyl (TBDPS) protecting group onto alcohols, phenols, and amines. The TBDPS group is prized for its significant steric hindrance, which provides excellent protection against a range of chemical conditions, including acidic and basic environments, as well as oxidative and reductive treatments. This robustness makes it a superior choice for multi-step syntheses where other silyl protecting groups might fail.

Beyond its role as a protecting group, Tert-Butylchlorodiphenylsilane is also a versatile intermediate in the synthesis of specialized chemicals and materials. It is employed in the preparation of silicon-based polymers and materials, where its incorporation can modify properties such as thermal stability, hydrophobicity, and dielectric characteristics. Such modified materials find applications in areas like advanced coatings, electronic components, and high-performance plastics. Its use in the synthesis of interphenylene phenyloxazoles, which have potential therapeutic applications in treating circulatory disorders, further underscores its importance in medicinal chemistry.

For professionals seeking to purchase Tert-Butylchlorodiphenylsilane, understanding its properties and applications is crucial for effective utilization. As a key supplier in the market, we emphasize the importance of sourcing from reputable manufacturers to ensure purity and consistent quality. Whether you are a researcher developing novel pharmaceuticals or a materials scientist engineering advanced composites, Tert-Butylchlorodiphenylsilane offers a unique blend of chemical resilience and synthetic utility. We are committed to providing high-quality reagents and supporting your chemical endeavors.