For scientists, researchers, and safety officers working with chemical compounds, a thorough understanding of their properties and handling requirements is non-negotiable. 4-Bromo-3-nitroanisole (CAS 10079-53-5) is a prominent chemical intermediate used in various synthesis pathways. This article provides insights into its key chemical properties and essential handling guidelines to ensure safe and effective use.

Key Chemical Properties of 4-Bromo-3-nitroanisole

4-Bromo-3-nitroanisole is characterized by its molecular formula C7H6BrNO3 and a molecular weight of approximately 232.03 g/mol. Its physical appearance is typically a colorless liquid, although variations in shade might occur depending on purity and storage conditions. The compound exhibits a density of around 1.70±0.1 g/cm³, indicating it is significantly denser than water.

A critical property for synthesis is its boiling point, which is reported as 153-154 °C at 13 mm Hg. This relatively high boiling point suggests it is not highly volatile under standard laboratory conditions. The flash point, being greater than 230 °F (>230 °C), indicates that it is not easily ignitable, which is a favorable safety characteristic for storage and handling. Its CAS number, 10079-53-5, serves as its unique identifier in chemical databases and regulatory documents.

The presence of the nitro group and bromine atom on the anisole ring makes this compound a versatile electrophilic and nucleophilic reagent, allowing for a range of chemical transformations. It is commonly used as an intermediate in the synthesis of more complex organic molecules, including those for pharmaceutical and agrochemical applications.

Safe Handling and Storage Recommendations

Despite its relatively high flash point, proper handling procedures must be followed to ensure safety when working with 4-Bromo-3-nitroanisole. As with most organic chemicals, it is advisable to handle it in a well-ventilated area, preferably under a fume hood, to avoid inhalation of any vapors. Personal protective equipment (PPE) such as chemical-resistant gloves, safety goggles, and a lab coat should always be worn.

In case of skin or eye contact, immediate flushing with plenty of water is recommended, followed by seeking medical attention. While specific toxicity data may vary, it is prudent to treat all chemical intermediates with caution. Material Safety Data Sheets (MSDS) or Safety Data Sheets (SDS) provided by the manufacturer or supplier are invaluable resources for detailed safety information, including first-aid measures, fire-fighting procedures, and accidental release measures.

Storage conditions are also important for maintaining the compound's integrity and safety. The source material suggests keeping the containers tightly closed when not in use. Storing in a cool, dry place, away from direct sunlight and incompatible materials, is recommended. For bulk quantities, typical packaging includes 200kg drums, and storage guidelines often include refrigeration (e.g., 2-8°C) as indicated by some suppliers for long-term stability.

Sourcing and Technical Support

When procuring 4-Bromo-3-nitroanisole, buyers should always request the most up-to-date SDS from their supplier. Reputable manufacturers and suppliers, such as those offering direct price inquiries and bulk purchase options from China, are well-equipped to provide this critical documentation. They can also offer technical support regarding the compound’s properties and suitability for specific synthesis routes.

In summary, understanding the physical and chemical properties of 4-Bromo-3-nitroanisole, coupled with strict adherence to safety protocols during handling and storage, is essential for its effective and safe utilization in chemical synthesis. Always consult the SDS and work with trusted suppliers for your chemical intermediate needs.