NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-quality chemical compounds and providing essential information for their safe and effective use. Among our extensive catalog, 2,2,2-Trichloroethyl Chloroformate is a key reagent with specific chemical properties that users must understand for optimal application. Its role in organic synthesis, particularly in peptide chemistry, hinges on its reactivity and, importantly, its handling requirements.

2,2,2-Trichloroethyl Chloroformate is characterized by its distinct physical appearance – typically a clear, colorless to pale yellow liquid, with a pungent, lachrymatory odor. Its chemical formula, C3H2Cl4O2, and molecular weight of approximately 211.85 g/mol, highlight its composition. A crucial property is its sensitivity to moisture, which can lead to hydrolysis. Therefore, it must be stored under an inert atmosphere, such as argon, and kept in tightly sealed amber glass containers to protect it from light and air. The recommended storage temperature is often as low as -20°C to maintain its stability and shelf life, which is typically around 3 months for an unopened container.

The reactivity of 2,2,2-Trichloroethyl Chloroformate makes it an excellent reagent for introducing the trichloroethoxycarbonyl (Troc) protecting group. This group is particularly valuable for amines due to its selective removal via zinc reduction. Understanding its boiling point (95-97°C at 20 mmHg) and flash point (110°C) is also important for safety during handling and processing. When working with this chemical, appropriate personal protective equipment (PPE), including gloves, eye protection, and lab coats, is mandatory due to its potentially corrosive and irritating nature. Proper ventilation in the laboratory is also essential.

Sourcing 2,2,2-Trichloroethyl Chloroformate from a reputable supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures that you receive a product that adheres to strict quality standards and comes with comprehensive handling guidelines. Our commitment to providing researchers with reliable and well-characterized reagents empowers them to conduct their experiments safely and effectively. Whether you are involved in academic research or industrial production, understanding the chemical properties and proper handling of 2,2,2-Trichloroethyl Chloroformate is key to achieving successful synthetic outcomes.