Methyl 2-(2-hydroxyphenyl)acetate (CAS 22446-37-3) is a compound that holds significant interest for chemists and material scientists due to its unique molecular structure and resulting chemical properties. Understanding these characteristics is fundamental for its effective utilization as a synthetic intermediate, a research chemical, or a component in various formulations. As a B2B supplier, we emphasize the importance of detailed technical information for our clients in the R&D and product development sectors.

Physically, Methyl 2-(2-hydroxyphenyl)acetate typically presents as a white crystalline powder. This solid form, with a melting point ranging from 122-124°C, is convenient for handling, storage, and precise measurement in laboratory settings. Its molecular formula, C9H10O3, and a molecular weight of approximately 166.17 g/mol, are critical for stoichiometric calculations in chemical reactions. The compound exhibits moderate solubility in organic solvents, which is a common trait for many aromatic esters.

Chemically, the molecule is distinguished by the presence of two primary functional groups: a phenolic hydroxyl group (-OH) attached to the phenyl ring and a methyl ester group (-COOCH3) on the acetic acid side chain. The phenolic hydroxyl group confers weakly acidic properties and makes the aromatic ring susceptible to electrophilic substitution reactions. The ortho-positioning of this hydroxyl group relative to the acetic acid moiety is notable; it can participate in intramolecular hydrogen bonding, influencing the molecule's conformation, polarity, and reactivity. This intramolecular interaction can impact its physical properties and its behavior in solution.

The methyl ester group is susceptible to nucleophilic attack, making it a site for hydrolysis (to yield the parent acid and methanol), transesterification (to form different esters), or reduction (to yield the corresponding alcohol). These reactions are foundational to its utility as a synthetic intermediate, allowing chemists to modify the molecule and build more complex structures.

The reactivity profile of Methyl 2-(2-hydroxyphenyl)acetate is exploited in various synthetic pathways. For instance, it is a key precursor in the synthesis of azoxystrobin, where its structure is modified and incorporated into the final fungicidal molecule. Researchers also utilize its reactive sites to create novel derivatives for drug discovery, exploring its potential as a building block for new therapeutic agents. The compound's stability is generally good under standard storage conditions (cool, dry, ventilated, and away from oxidizing agents), but prolonged exposure to extreme conditions or reactive chemicals should be avoided.

For researchers and product developers requiring this compound, ensuring its identity and purity is paramount. Analytical techniques such as NMR, IR spectroscopy, and Mass Spectrometry are employed to confirm its structure and assess its quality. At NINGBO INNO PHARMCHEM CO.,LTD., we provide comprehensive technical specifications and ensure that our Methyl 2-(2-hydroxyphenyl)acetate meets the high standards expected by the industry. We are your reliable partner for sourcing this important chemical intermediate. Contact us to discuss your specific requirements.