For professionals in the chemical industry, understanding the detailed properties and safety protocols of the materials they work with is non-negotiable. 2-Acetyl-4-chlorothiophene, known by its CAS number 34730-20-6, is a specialized organic intermediate that requires careful handling and a thorough understanding of its characteristics. This article provides a comprehensive overview of its chemical properties and safety guidelines, crucial for anyone looking to purchase or utilize it, especially when sourcing from Chinese manufacturers.

2-Acetyl-4-chlorothiophene presents as a light yellow liquid, with its molecular formula C6H5ClOS and a molecular weight of 160.62 g/mol. Key physical properties include a density of approximately 1.334 g/mL and a predicted boiling point of around 263.0° C at 760 mmHg. Its insolubility in water necessitates the use of appropriate organic solvents for reactions and handling. The compound's chemical reactivity stems from the acetyl group and the chlorinated thiophene ring, making it a versatile intermediate for various synthetic pathways, including palladium-catalyzed cross-coupling reactions frequently employed in pharmaceutical and agrochemical research.

Safety considerations are paramount when dealing with 2-Acetyl-4-chlorothiophene. It is classified as a hazardous material for transport, often carrying UN numbers and specific hazard classes (e.g., Class 6.1). Safety Data Sheets (SDS) typically indicate hazard statements such as H302 (Harmful if swallowed), H312 (Harmful in contact with skin), and H331 (Toxic if inhaled). Precautionary statements emphasize the need for proper personal protective equipment (PPE), including gloves, eye protection, and respiratory protection, along with working in well-ventilated areas or under fume hoods. When you buy from Chinese suppliers, always ensure they provide an up-to-date SDS.

When procuring 2-Acetyl-4-chlorothiophene, it is vital to partner with manufacturers who rigorously adhere to safety standards and provide comprehensive safety documentation. Reputable Chinese suppliers will have robust quality control measures in place to ensure the product's integrity and will offer guidance on safe handling and storage. Understanding these aspects before purchase is essential for minimizing risks and ensuring compliant usage in your laboratory or production facility.

In summary, 2-Acetyl-4-chlorothiophene (CAS 34730-20-6) is a potent chemical intermediate with specific properties and handling requirements. By prioritizing safety and sourcing from established Chinese manufacturers who provide thorough documentation, professionals can effectively and responsibly integrate this compound into their work.