3-Chloro-5-nitrobenzotrifluoride, identified by CAS number 401-93-4, is a chemically significant aromatic compound that serves as a critical intermediate in various synthesis applications. Its molecular structure, C7H3ClF3NO2, features a benzene ring substituted with a chlorine atom, a nitro group, and a trifluoromethyl group. This specific arrangement of functional groups imparts unique chemical properties that make it highly valuable in organic synthesis.

The compound's physical appearance is described as a colorless to light yellow transparent liquid. Its stability at room temperature is a key attribute, allowing for relatively straightforward handling and storage. Furthermore, its solubility in common organic solvents, such as alcohols, ketones, and esters, facilitates its integration into diverse reaction environments. This solubility profile is crucial for chemists aiming to perform various synthetic transformations efficiently.

Chemically, the presence of electron-withdrawing groups—the nitro and trifluoromethyl moieties—significantly influences the reactivity of the benzene ring. These groups typically deactivate the ring towards electrophilic aromatic substitution but can activate it towards nucleophilic aromatic substitution under certain conditions. This predictable reactivity pattern makes 3-Chloro-5-nitrobenzotrifluoride a versatile building block for chemists looking to introduce specific functionalities or modify existing structures.

Its primary use is as an intermediate in the production of pesticides, dyes, and pharmaceuticals. In organic synthesis, it is employed to introduce or modify key functional groups on aromatic systems. For example, the nitro group can be reduced to an amine, opening pathways to new amine derivatives, or the chlorine atom can be displaced in nucleophilic substitution reactions. The trifluoromethyl group contributes lipophilicity and metabolic stability, which are often desirable characteristics in biologically active compounds.

Understanding these chemical properties is essential for chemists and procurement specialists who seek to leverage 3-Chloro-5-nitrobenzotrifluoride in their research and development or manufacturing processes. By understanding its behavior, one can effectively design synthetic routes and ensure the successful creation of complex target molecules.