For chemists engaged in organic synthesis, understanding the fundamental properties and preparation of key intermediates is crucial for successful project execution. Dioxidine (CAS 17311-31-8) is one such compound, a valuable reagent whose chemical characteristics dictate its applications and handling requirements. This article explores the known chemical properties, synthesis pathways, and important safety considerations for Dioxidine.

Dioxidine, chemically known as 2,3-Quinoxalinedimethanol, 1,4-dioxide, presents as a yellow crystalline solid. Its molecular formula is C10H10N2O4, with a molecular weight of 222.20 g/mol. A significant physical property often cited is its melting point, typically around 171-172°C, which may involve decomposition. The compound's solubility profile indicates it is slightly soluble in DMSO and methanol, especially when heated. These solubility characteristics are important for its use in various reaction media and purification processes.

While the original source material mentioned its use as a 'useful compound for identification of triazole and imidazole derivatives as antitubercular agents,' more contemporary uses focus on its role as a versatile intermediate in organic synthesis. Its structure, featuring a quinoxaline core with two hydroxymethyl groups and N-oxide functionalities, provides reactive sites for further chemical modifications. The precise synthesis route is often proprietary to manufacturers, but generally involves established organic chemistry principles to assemble the quinoxaline ring system and introduce the desired functional groups.

Information regarding the stability and reactivity of Dioxidine is important for safe handling and storage. While not explicitly described as highly unstable in all sources, compounds with N-oxide functionalities can sometimes exhibit sensitivity. Standard storage recommendations for fine chemicals often suggest keeping Dioxidine in a cool, dry place, away from direct sunlight and incompatible materials. For chemical manufacturers and bulk purchasers, understanding the shelf life and recommended storage temperatures (e.g., -20°C Freezer is sometimes mentioned) is critical for maintaining product integrity.

Safety information often classifies Dioxidine as an irritant. Therefore, appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and lab coats, should always be worn when handling the compound. Adequate ventilation in the workspace is also recommended. When looking to buy Dioxidine, engage with suppliers who provide comprehensive safety data sheets (SDS) detailing hazard information, handling precautions, and emergency procedures. This due diligence ensures that your procurement process prioritizes the safety of personnel and compliance with regulations.