Ethyl 2-chloroacetoacetate, identified by its CAS number 609-15-4, is a compound of significant interest in the chemical industry due to its unique properties and broad utility. This colorless to pale yellow liquid possesses a characteristic odor and exhibits high reactivity stemming from its dual functional groups: an alpha-chloro substituent and a ketone adjacent to an ester. These characteristics make it an exceptionally valuable intermediate in various chemical synthesis processes.

The synthesis of ethyl 2-chloroacetoacetate typically involves the chlorination of ethyl acetoacetate. While various methods exist, controlling reaction conditions is paramount to achieving high purity and yield while minimizing unwanted byproducts, such as dichloro derivatives. One efficient approach involves the solvent-free reaction of ethyl acetoacetate with sulfuryl chloride at controlled low temperatures, which minimizes waste and simplifies post-reaction processing. Key factors influencing yield and purity include precise temperature control, stoichiometric ratios, and effective post-reaction workup, often involving vacuum distillation.

Understanding the chemical properties of ethyl 2-chloroacetoacetate, such as its solubility (miscible with organic solvents, slightly soluble in water) and boiling point, is crucial for its handling and application. Its reactivity profile allows it to participate in nucleophilic substitution reactions and condensation reactions, forming key intermediates for pharmaceuticals and agrochemicals.

NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality ethyl 2-chloroacetoacetate, adhering to strict quality control measures throughout its production. We aim to equip researchers and industrial chemists with a reliable and pure product, facilitating successful application in diverse chemical synthesis projects. Our focus on providing detailed information about the synthesis and properties of CAS 609-15-4 supports informed decision-making and efficient utilization of this vital chemical intermediate.