For professionals in the chemical industry, a deep understanding of chemical intermediates is key to unlocking innovation and optimizing production processes. 4-Fluorophthalic Anhydride (CAS 319-03-9) is a significant organic intermediate renowned for its versatile chemical properties and extensive synthesis potential. This article aims to provide a detailed overview of its characteristics and why it's a sought-after compound for manufacturers and researchers.

Chemical Profile of 4-Fluorophthalic Anhydride

4-Fluorophthalic Anhydride is an aromatic anhydride with the molecular formula C8H3FO3. Its structure features a phthalic anhydride core with a fluorine atom attached to the aromatic ring at the 4-position. This fluorine atom significantly influences the electron distribution within the molecule, impacting its reactivity and the properties of the resulting derivatives. It typically presents as a white crystalline powder with a melting point in the range of 74-75°C. The compound's purity is a critical factor for its applications, with high-grade versions reaching 99.5% or more. Its relatively low volatility and stability under normal storage conditions make it a practical intermediate to handle and process.

Reactivity and Synthesis Potential

The anhydride functional group in 4-Fluorophthalic Anhydride is highly susceptible to nucleophilic attack. This reactivity forms the basis of its extensive use in synthesis:

  • Esterification: Reaction with alcohols yields fluorinated phthalate esters, which can find applications in plasticizers, lubricants, or as components in polymers.
  • Amidation: Reaction with amines produces fluorinated phthalimides or amic acids, which are important intermediates in the synthesis of pharmaceuticals, dyes, and polymers like polyimides.
  • Ring-Opening Reactions: The anhydride ring can be opened by water to form 4-fluorophthalic acid, which itself can be a useful reagent or intermediate.
  • Electrophilic Aromatic Substitution: While the anhydride group is deactivating, the presence of fluorine can influence further substitutions on the aromatic ring under specific conditions.

These reactions allow for the introduction of the fluorophthalic moiety into a vast array of complex organic molecules, making it a cornerstone for creating novel materials and active compounds in industries ranging from pharmaceuticals and agrochemicals to advanced materials science.

Sourcing High-Quality 4-Fluorophthalic Anhydride

For businesses looking to buy 4-Fluorophthalic Anhydride, it is essential to source from reliable manufacturers that can guarantee high purity and consistent supply. NINGBO INNO PHARMCHEM CO.,LTD. serves as a prime example of a manufacturer and supplier in China that offers this vital intermediate. We provide detailed product specifications, including purity levels and physical characteristics, to meet the exacting demands of our B2B clients. We encourage you to request a quote and sample to assess the quality and suitability for your specific synthesis needs. Partnering with a trusted supplier ensures that your production processes are supported by a stable and high-quality raw material.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing the chemical industry with essential building blocks like 4-Fluorophthalic Anhydride, manufactured to the highest standards.