In the realm of fine chemicals, understanding the properties and applications of key reagents is crucial for effective utilization. Hexamethyldisilazane (HMDS), identified by CAS number 999-97-3, is a compound that stands out for its unique silicon-based chemistry and broad applicability. From facilitating intricate organic syntheses to enhancing material surfaces, HMDS is a valuable asset for researchers and industrial chemists alike. As a prominent manufacturer and supplier of HMDS in China, we aim to provide comprehensive information on this versatile chemical, guiding you on how to purchase it for your specific needs.

Understanding the Chemical Profile of HMDS

Hexamethyldisilazane, with the molecular formula C6H19NSi2, is a clear, colorless liquid. Its chemical structure features a central nitrogen atom bonded to two trimethylsilyl groups ([ (CH3)3Si ]2NH). This structure is key to its reactivity:

  • Silylating Agent: The most significant chemical property of HMDS is its role as a silylating agent. It readily reacts with compounds containing active hydrogen atoms (such as alcohols, amines, and carboxylic acids) to introduce the trimethylsilyl (TMS) group. This reaction typically proceeds with the liberation of ammonia as a byproduct. The silylation process is often used for protection of functional groups, increasing volatility for analysis, or modifying solubility.
  • Basicity: HMDS is a moderately strong base due to the presence of the nitrogen atom. It can be used as a non-nucleophilic base in certain organic reactions.
  • Hydrolytic Sensitivity: Like many silazanes, HMDS is sensitive to moisture and will react with water to form hexamethyldisiloxane and ammonia. Therefore, it must be stored and handled under anhydrous conditions.

Key Physical Properties:

  • Appearance: Colorless transparent liquid
  • Boiling Point: Approximately 127°C (260°F)
  • Flash Point: Typically around 7.4°C (45.3°F), indicating it is a flammable liquid.
  • Density: Around 0.77 g/cm³ at 25°C.
  • Purity: Commonly available at ≥99% purity, essential for demanding applications.

Diverse Applications of HMDS

The chemical properties of HMDS lend themselves to a wide array of applications:

  • Organic Synthesis: As a silylating agent, it's crucial for protecting functional groups in complex multi-step syntheses, aiding in the creation of diverse organic molecules.
  • Pharmaceutical Intermediates: HMDS is employed in the synthesis of various pharmaceutical intermediates, contributing to the production of life-saving medicines.
  • Semiconductor Manufacturing: In photolithography, HMDS is used as an adhesion promoter for photoresists on silicon wafers, ensuring higher yields and better precision in microchip fabrication.
  • Surface Modification: It is used to create hydrophobic surfaces on materials like silica, glass, and certain powders, impacting properties relevant to coatings, composites, and chromatography.
  • Biotechnology: HMDS can be used in preparing samples for microscopy, enhancing contrast or surface properties.

Sourcing HMDS: The Value of a China Manufacturer

For industries requiring HMDS, sourcing from a reputable China manufacturer offers significant advantages. We provide high-quality HMDS (CAS 999-97-3) with guaranteed purity, crucial for sensitive applications. Our competitive pricing and stable supply chain ensure that businesses can procure this essential chemical efficiently and cost-effectively. Whether you need small quantities for research or bulk orders for industrial production, our facilities are equipped to meet your demands.

When you look to buy Hexamethyldisilazane, consider our offerings. We are committed to delivering exceptional chemical products and supporting your innovative endeavors. Explore the chemical versatility of HMDS and how our reliable supply can benefit your operations.