Organic synthesis is the cornerstone of innovation in the chemical and pharmaceutical industries. For researchers and formulators, access to versatile building blocks that enable the construction of complex molecules is essential. 1-Bromo-3,5-difluorobenzene (CAS 461-96-1) stands out as a highly valuable intermediate due to its unique chemical structure and reactivity, making it a preferred choice for a wide range of synthetic applications. As a dedicated supplier of fine chemicals, we recognize the importance of this compound for cutting-edge R&D.

1-Bromo-3,5-difluorobenzene, a clear, colorless to light yellow liquid, possesses a benzene ring functionalized with a bromine atom and two fluorine atoms at the meta positions. This specific arrangement imparts distinctive electronic properties and reactivity patterns. The bromine atom serves as an excellent leaving group, readily participating in various metal-catalyzed cross-coupling reactions. These include:

  • Suzuki-Miyaura Coupling: Reacting with organoboron compounds to form new carbon-carbon bonds, enabling the synthesis of biaryls and other substituted aromatics.
  • Heck Reaction: Coupling with alkenes to form substituted styrenes or other vinyl aromatic compounds.
  • Sonogashira Coupling: Reaction with terminal alkynes to introduce alkynyl functionalities.
  • Buchwald-Hartwig Amination: Forming carbon-nitrogen bonds by coupling with amines.

These powerful synthetic methodologies allow chemists to precisely build complex molecular architectures with the 3,5-difluorophenyl moiety. This moiety is often sought after in medicinal chemistry for its influence on drug properties, such as metabolic stability and lipophilicity. For anyone looking to buy 1-Bromo-3,5-difluorobenzene for their research, understanding its reactivity profile is key to designing efficient synthetic routes.

Beyond cross-coupling reactions, the fluorine atoms on the benzene ring can also influence reactivity in other ways, such as activating or deactivating specific positions for electrophilic or nucleophilic aromatic substitution. The presence of fluorine can also increase the thermal and chemical stability of the resulting compounds.

As a leading manufacturer and supplier in China, we ensure that our 1-Bromo-3,5-difluorobenzene meets stringent purity standards (99% minimum), which is critical for the success of these sensitive catalytic reactions. Impurities can poison catalysts or lead to unwanted side products, complicating downstream purification. Therefore, sourcing from a reliable manufacturer who can provide consistent quality and comprehensive technical support is invaluable for research scientists.

Whether you are developing new pharmaceuticals, advanced materials, or specialty chemicals, 1-Bromo-3,5-difluorobenzene offers a versatile entry point into the synthesis of difluorinated aromatic compounds. We encourage researchers and procurement managers to explore its potential and to contact us for inquiries regarding pricing and bulk orders. Securing this key intermediate from a trusted supplier will significantly contribute to the efficiency and success of your synthetic endeavors.