For researchers, R&D scientists, and product formulators, a deep understanding of the chemical properties and synthesis of key intermediates is essential for successful project outcomes. 12-Bromo-1-dodecene, identified by CAS number 99828-63-4, is a prime example of such a compound, offering a unique combination of a long aliphatic chain, a terminal alkene, and a primary bromide. This article provides a professional overview of its chemistry, synthesis, and handling considerations.

The molecular formula of 12-bromo-1-dodecene is C12H23Br, with a molecular weight of approximately 247.215 g/mol. Its physical appearance is typically described as a colorless transparent liquid. Key physicochemical properties include a predicted density of 1.052 ± 0.06 g/cm³ and a boiling point around 270.2 ± 9.0 °C. These characteristics are important for process design and handling in industrial settings. Its limited solubility in water and good solubility in common organic solvents also dictate its usage in various reaction media.

The synthesis of 12-bromo-1-dodecene typically involves the selective bromination of a precursor. One common route involves the bromination of 11-undecenol or related long-chain alcohols or alkenes. Methods often employ reagents like triphenylphosphine in conjunction with carbon tetrabromide, or radical bromination techniques. For instance, the reaction of 11-undecenol with a triphenylphosphine/carbon tetrabromide system in a suitable solvent, followed by workup, yields the desired product. Manufacturers often optimize these processes to achieve high purity (e.g., ≥97.0%) and good yields, making the compound readily available for purchase.

From a reactivity standpoint, the primary bromide is susceptible to nucleophilic substitution reactions. This allows for the introduction of various functional groups, such as amines, alcohols, thiols, or carbanions, through reactions with appropriate nucleophiles. The terminal alkene can undergo addition reactions, polymerization, or be utilized in olefin metathesis. This dual functionality is what makes 12-bromo-1-dodecene a valuable intermediate for custom synthesis and the development of complex organic molecules. Scientists looking to buy this compound for their research can expect a reliable and reactive building block.

Handling 12-bromo-1-dodecene requires standard laboratory safety precautions for organobromine compounds. It should be stored in a closed container, preferably in a cool, dry, and well-ventilated area, away from incompatible materials like strong oxidizers. While not highly volatile, good laboratory practices, including the use of personal protective equipment (PPE) such as gloves and safety glasses, are recommended. For bulk purchases, ensuring compliance with shipping and storage regulations is a responsibility of both the supplier and the buyer.

In summary, understanding the chemical nature, synthetic accessibility, and safe handling of 12-bromo-1-dodecene empowers professionals to leverage its potential effectively. Whether you are a scientist seeking to buy this intermediate for groundbreaking research or a formulator developing new products, its chemical characteristics offer a robust platform for innovation.