For chemists and material scientists, a deep understanding of key chemical intermediates is vital for successful research and development. 2-Bromophenetole, known by its CAS number 583-19-7, is a compound that warrants attention due to its versatility in organic synthesis. This article will explore the chemical synthesis routes, physicochemical properties, and various applications of 2-Bromophenetole, offering insights for professionals looking to buy 2-Bromophenetole or simply understand its role in chemistry.

Synthesis Pathways for 2-Bromophenetole

2-Bromophenetole (C8H9BrO) can be synthesized through several established organic chemistry methodologies. One common approach involves the Williamson ether synthesis. This typically starts with 2-bromophenol, which is deprotonated with a base (such as sodium hydroxide or potassium carbonate) to form the phenoxide anion. This anion then reacts with an ethylating agent, like ethyl bromide or diethyl sulfate, to form the desired ether linkage. The reaction conditions, including solvent choice and temperature, are optimized to maximize yield and purity.

Another potential route could involve the bromination of phenetole (ethoxybenzene). However, directing the bromine to the ortho position specifically can be challenging and may require careful control of reaction conditions or the use of directing groups.

For industrial-scale production, manufacturers focus on cost-effective and scalable synthesis routes, ensuring the final product meets strict quality standards. If you are seeking to purchase 1-bromo-2-ethoxybenzene, inquire about the synthesis method used by the 2-Bromophenetole supplier China, as this can sometimes impact trace impurities.

Physicochemical Properties and Handling

2-Bromophenetole is recognized for its key properties:

  • Molecular Formula: C8H9BrO
  • Molecular Weight: Approximately 201.06 g/mol
  • Appearance: Typically a clear, colourless oil.
  • Boiling Point: Around 223°C.
  • Density: Approximately 1.3646 g/cm³.
  • Solubility: Soluble in organic solvents like chloroform and methanol, but sparingly soluble in water.

Proper handling and storage are essential. As with many halogenated organic compounds, it should be stored in a cool, dry, and well-ventilated area, away from ignition sources and incompatible materials. Safety data sheets (SDS) provide comprehensive information on hazard statements and precautionary measures.

Diverse Applications in Chemistry

The functional groups present in 2-Bromophenetole make it a versatile intermediate:

  • Pharmaceutical Intermediates: Its structure is a valuable scaffold for building complex drug molecules through reactions like Suzuki coupling, Buchwald-Hartwig amination, and Grignard reactions.
  • Agrochemicals: It can be used in the synthesis of pesticides and herbicides.
  • Material Science: It may find applications in the development of specialty polymers and organic electronic materials.
  • Research Reagent: It is widely used in academic and industrial research laboratories for developing new synthetic methodologies and exploring novel compounds.

For R&D scientists, understanding the CAS 583-19-7 price is crucial for budgeting experimental work. Direct inquiries to manufacturers are often the best way to obtain accurate pricing and availability.

In conclusion, 2-Bromophenetole is a fundamental intermediate in organic chemistry. Its accessible synthesis, characteristic properties, and broad applicability underscore its importance. By understanding these aspects, chemists can effectively source and utilize this compound for their synthetic endeavors.