In the realm of advanced organic chemistry, hypervalent iodine compounds have carved out a significant niche due to their unique reactivity and broad applicability. Diacetoxyiodobenzene (CAS 3240-34-4), also known as Phenyliodine diacetate (PIDA), is a prime example of such a reagent. As a leading supplier and manufacturer, we aim to provide clarity on its chemical profile and the indispensable role it plays in modern chemical synthesis.

Understanding the Chemical Nature of Diacetoxyiodobenzene

Diacetoxyiodobenzene (CAS 3240-34-4) is characterized by its iodine atom being in the +3 oxidation state, forming bonds with two acetoxy groups and a phenyl group. This structure, classified as hypervalent iodine, grants it distinct oxidizing capabilities. Typically appearing as a white to light yellow crystalline powder, it exhibits good stability under appropriate storage conditions (cool, dry, and protected from light). Its molecular formula, C10H11IO4, and a molecular weight of approximately 322.10 g/mol, are key identifiers for procurement and formulation. The compound's solubility in organic solvents like acetonitrile and dichloromethane, while being insoluble in water, dictates its handling and reaction conditions.

Key Synthetic Applications Driven by its Chemistry

The chemical properties of Diacetoxyiodobenzene make it an invaluable tool for chemists engaged in complex synthesis:

  • Oxidation Reactions: Its primary function is as a versatile oxidizing agent. It's particularly noted for its use in oxidative decarboxylation of 2-aryl carboxylic acids to produce aldehydes, ketones, and nitriles. This transformation is critical in building carbon frameworks.
  • Pharmaceutical Intermediates: The reagent's ability to participate in key synthetic steps makes it essential for producing intermediates of high-value pharmaceuticals, such as Irinotecan.
  • Functionalization of Organic Molecules: Diacetoxyiodobenzene enables various functionalization reactions, including hydroxylations and the cleavage of vicinal diols, allowing for precise molecular modification.
  • Catalysis and Reagent Design: Its structure and reactivity also make it a subject of study for developing new catalytic systems and innovative synthetic methodologies.

Why Source from a Reliable Manufacturer?

For businesses and research institutions, sourcing Diacetoxyiodobenzene necessitates partnering with a supplier that guarantees quality and consistency. As a manufacturer, we adhere to strict quality control protocols to ensure our product meets the highest purity standards, typically above 98%. This commitment ensures that your synthetic processes yield predictable and reproducible results, minimizing batch failures and maximizing efficiency. Whether you need it for R&D or large-scale manufacturing, understanding the chemical specifications and reliable availability is crucial. We offer competitive pricing and a stable supply chain, ensuring you can always buy this essential reagent.

If you are looking to integrate Diacetoxyiodobenzene into your synthetic strategies, reaching out to us for a quote is the first step towards a reliable partnership.