Chloroacetyl chloride (CAS: 79-04-9) is a compound defined by its chemical structure and reactivity, making it a vital player in organic synthesis. Understanding its core properties, the methods by which it is produced, and the necessary safety measures for its handling is fundamental for any chemist or manufacturer utilizing this versatile intermediate.

Chemically, chloroacetyl chloride is an acyl chloride with the formula ClCH2COCl. Its molecular weight is approximately 112.94 g/mol. Key physical properties include its appearance as a colorless transparent liquid with a pungent odor. It is miscible with many organic solvents but reacts vigorously with water, releasing hydrogen chloride gas. This reactivity is precisely what makes it such a valuable chemical synthesis component, particularly as an acylating agent.

The chloroacetyl chloride manufacturing process typically involves the chlorination of acetyl chloride. This reaction, carried out under specific conditions, yields the desired product. The efficiency and purity of the chloroacetyl chloride obtained are critical for its downstream applications, especially in the demanding pharmaceutical and agrochemical sectors. Ensuring high assay percentages, such as 99% min for chloroacetyl chloride and low levels of impurities like dichloroacetyl chloride, is a hallmark of quality production.

Handling chloroacetyl chloride demands utmost care due to its corrosive and irritating nature. Safety precautions for chloroacetyl chloride are paramount to prevent exposure and accidents. This includes the mandatory use of personal protective equipment (PPE) such as chemical-resistant gloves, safety goggles with side shields, and protective clothing. Working in a well-ventilated environment, ideally a fume hood, is essential to minimize exposure to its vapors. Proper storage is also critical; it should be kept in tightly sealed containers in a cool, dry, and well-ventilated area, away from moisture, heat sources, and incompatible substances like alcohols, amines, and strong bases.

For those looking to integrate chloroacetyl chloride into their operations, understanding the chloroacetyl chloride price and sourcing it from reputable suppliers is key. Online platforms offer a convenient way to buy chloroacetyl chloride, but careful evaluation of suppliers regarding quality, consistency, and adherence to safety standards is recommended. The chemical synthesis of pharmaceuticals and agrochemicals relies heavily on the integrity of intermediates like chloroacetyl chloride.

In summary, the chemistry of chloroacetyl chloride is characterized by its reactivity and broad applicability. By understanding its properties, manufacturing processes, and implementing stringent safety measures, industries can effectively harness the power of this essential chemical intermediate for innovation and production.