Ethyldiisopropylamine (DIPEA), often referred to by its common name Hunig's base, is a chemical compound that has become an indispensable tool in the arsenal of organic chemists. Its unique structural features impart a set of chemical properties that make it exceptionally useful for specific synthetic challenges, particularly where selectivity and reaction control are critical. Understanding these properties is key to leveraging DIPEA effectively in various industrial and research applications.

The molecular formula of Ethyldiisopropylamine is C8H19N, with a molecular weight of approximately 129.24 g/mol. Its structure consists of a central nitrogen atom bonded to one ethyl group and two isopropyl groups. The significant steric bulk of the two isopropyl groups is the defining characteristic of DIPEA. This steric hindrance profoundly influences its reactivity. While it possesses the basicity characteristic of a tertiary amine, capable of accepting protons (pKa ~10.98), the bulky isopropyl groups sterically impede the nitrogen lone pair from readily attacking electrophilic centers. This makes DIPEA a poor nucleophile, a trait that is highly advantageous in many organic syntheses.

Physically, DIPEA is typically a colorless liquid with a distinct amine odor. It has a relatively low boiling point (around 127 °C) and a low flash point (around 6 °C), classifying it as a highly flammable substance that requires careful handling and storage in well-ventilated areas, away from ignition sources. Its miscibility with most organic solvents, such as acetone and ethanol, further enhances its utility as a reagent and solvent in various reaction media. Its density is approximately 0.742 g/mL at 25 °C.

The primary applications of DIPEA stem directly from its chemical properties. As a strong, non-nucleophilic base, it is widely used in organic synthesis as a proton scavenger. This is critical in reactions that generate acidic byproducts, such as esterifications, acylations, and various coupling reactions. By neutralizing these acids, DIPEA drives the reactions forward and prevents degradation of sensitive reactants or products. In peptide synthesis, it is instrumental in promoting amino acid coupling while minimizing racemization. Its role in palladium-catalyzed reactions, such as alkoxycarbonylation, is also significant, where it acts as an acid scavenger.

For professionals seeking to buy Ethyldiisopropylamine, understanding these chemical properties is essential. Sourcing from a reputable Ethyldiisopropylamine manufacturer guarantees that the product meets the required specifications for purity and consistency, which is vital for reproducible results. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing high-quality DIPEA, catering to the demands of pharmaceutical, agrochemical, and fine chemical industries. Their expertise ensures that customers receive a reliable and effective reagent for their synthesis needs.