The Chemistry of 1-Chlorooctadecane (CAS 3386-33-2): Properties and Synthesis Pathways
NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing detailed insights into the chemicals we offer, and today we explore the fascinating chemistry behind 1-Chlorooctadecane (CAS 3386-33-2). Understanding its fundamental properties and common synthesis pathways is crucial for chemists and researchers utilizing this important fine chemical intermediate in their work.
1-Chlorooctadecane, with its molecular formula C18H37Cl, is a saturated long-chain alkyl halide. Its structure consists of an 18-carbon aliphatic chain terminated by a chlorine atom. This specific arrangement dictates its physical and chemical properties. Typically appearing as a clear, colorless to yellowish liquid upon melting, it possesses a high degree of purity, often exceeding 99%. This purity is essential for its reliable performance in chemical synthesis, particularly when employed as a chemical intermediate in the production of pharmaceuticals or specialty materials.
The reactivity of 1-Chlorooctadecane is primarily centered around the carbon-chlorine bond. This bond can undergo nucleophilic substitution reactions, making it a versatile reagent for introducing the octadecyl (C18H37) moiety into other molecules. For instance, reacting it with alkoxides can yield long-chain ethers, while reaction with amines can produce long-chain amines. These transformations are fundamental to its utility in various 1-chlorooctadecane applications.
The synthesis of 1-Chlorooctadecane typically involves the chlorination of octadecanol (stearyl alcohol) or octadecane. Common methods for converting octadecanol to 1-chlorooctadecane include reaction with thionyl chloride (SOCl2) or phosphorus trichloride (PCl3). These reactions are well-established in organic chemistry and allow for efficient production of the desired product. Alternatively, direct chlorination of octadecane under specific conditions can also yield 1-chlorooctadecane, though selectivity can be a challenge.
The 1-octadecyl chloride properties, such as its relatively high boiling point (347.8 °C at 760 mmHg) and low solubility in water, are characteristic of long-chain hydrocarbons. Its solubility in nonpolar organic solvents facilitates its use in various reaction media. When considering the purchase of this compound, understanding these properties helps in designing appropriate reaction and purification protocols. For manufacturers aiming to buy 1-chlorooctadecane, NINGBO INNO PHARMCHEM CO.,LTD. offers access to high-quality material, backed by rigorous quality control measures.
In essence, 1-Chlorooctadecane serves as a foundational building block in organic synthesis, enabling the creation of complex molecules with diverse applications. Its predictable reactivity and availability as a high-purity chemical intermediate make it a valuable asset for the chemical industry. NINGBO INNO PHARMCHEM CO.,LTD. is proud to supply this essential compound, supporting innovation and advancements in chemical manufacturing.
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Future Origin 2025
“Common methods for converting octadecanol to 1-chlorooctadecane include reaction with thionyl chloride (SOCl2) or phosphorus trichloride (PCl3).”
Core Analyst 01
“These reactions are well-established in organic chemistry and allow for efficient production of the desired product.”
Silicon Seeker One
“Alternatively, direct chlorination of octadecane under specific conditions can also yield 1-chlorooctadecane, though selectivity can be a challenge.”