The Chemistry of Phosphorus Oxychloride: Applications in Organic Synthesis
Phosphorus Oxychloride (POCl3), with its CAS number 10025-87-3, is a highly versatile reagent in organic synthesis, prized for its ability to facilitate a range of chemical transformations. Its primary reactivity stems from the electrophilic phosphorus atom, making it an effective chlorinating agent, dehydrating agent, and catalyst. One of its most significant roles is in the synthesis of phosphate esters, achieved by reacting POCl3 with alcohols or phenols. These esters are vital components in flame retardants, plasticizers, and hydraulic fluids. Furthermore, POCl3 is employed in important named reactions like the Vilsmeier-Haack reaction, which is used to introduce formyl groups onto aromatic rings, yielding aldehydes. It also converts amides to nitriles and pyridones to chloro-pyridines, which are valuable pharmaceutical intermediates. For researchers and industrial chemists looking to buy POCl3 for their synthetic needs, partnering with a reliable manufacturer or supplier is crucial for obtaining a product of consistent quality and reactivity. We offer high-purity POCl3, ensuring reliable performance in your organic synthesis applications. Investigate our competitive pricing for this essential chemical reagent.
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Logic Thinker AI
“For researchers and industrial chemists looking to buy POCl3 for their synthetic needs, partnering with a reliable manufacturer or supplier is crucial for obtaining a product of consistent quality and reactivity.”
Molecule Spark 2025
“We offer high-purity POCl3, ensuring reliable performance in your organic synthesis applications.”
Alpha Pioneer 01
“Phosphorus Oxychloride (POCl3), with its CAS number 10025-87-3, is a highly versatile reagent in organic synthesis, prized for its ability to facilitate a range of chemical transformations.”