Potassium Tert-Butoxide (KOtBu, CAS 865-47-4) is a compound that chemists frequently turn to when a potent, sterically hindered base is required. Its distinctive properties make it indispensable in a wide array of organic synthesis applications, ranging from fundamental laboratory research to industrial-scale production of pharmaceuticals and agrochemicals.

At its core, KOtBu is an alkoxide, formed from the deprotonation of tert-butanol. Its chemical formula, KOC(CH3)3, reveals the tert-butyl group attached to the oxygen. This bulky tert-butyl group is the key to its unique behavior. It shields the basic oxygen atom, significantly reducing its nucleophilicity while preserving its strong basic character. This dual nature—strong base, weak nucleophile—is precisely what makes it so valuable. When researchers look to buy Potassium Tert-Butoxide, they are often seeking this specific combination of properties for precise reaction control.

Key Chemical Properties and Reactivity

The strong basicity of KOtBu, often indicated by the pKa of its conjugate acid being around 17 in water, allows it to efficiently deprotonate even weakly acidic protons. This is fundamental for generating carbanions, which are critical intermediates in many carbon-carbon bond-forming reactions. Furthermore, its steric bulk is a defining characteristic that directs its reactivity, particularly in elimination reactions. In E2 eliminations, KOtBu typically abstracts a proton from the less substituted beta-carbon, leading to the formation of the Hofmann product – a regioselectivity that is often challenging to achieve with less hindered bases.

When considering its synthesis, KOtBu is typically prepared by the reaction of potassium metal with anhydrous tert-butanol. This reaction must be carried out under strictly anhydrous conditions, as KOtBu is highly sensitive to moisture, reacting vigorously with water to form tert-butanol and potassium hydroxide. This reactivity underscores the importance of proper handling and storage. For commercial purposes, it is often provided as a solid powder or in solution form, with manufacturers ensuring high purity, typically 99% or more, to meet the demands of various applications. Understanding the Potassium Tert-Butoxide price in relation to its purity is crucial for procurement decisions.

Ensuring Quality from Your Supplier

For industries relying on KOtBu, securing a consistent supply of high-quality material is paramount. Partnering with a reputable manufacturer and supplier, especially one with established operations like those found in China, ensures access to product that meets stringent specifications. A reliable supplier will not only provide the required purity but also ensure appropriate packaging to protect the hygroscopic nature of the reagent. This attention to detail is why many organizations choose to buy Potassium Tert-Butoxide from trusted sources.

The technical data sheet for CAS 865-47-4 will often detail its physical properties, chemical reactivity, and recommended handling procedures. By thoroughly reviewing this information and understanding the specific needs of your synthesis, you can make an informed decision about which supplier best meets your requirements. Competitive Potassium Tert-Butoxide pricing should always be considered alongside the supplier's commitment to quality assurance and supply chain stability.

In summary, Potassium Tert-Butoxide is a cornerstone reagent in modern organic chemistry due to its potent basicity, steric hindrance, and selective reactivity. Its applications are widespread, contributing significantly to advancements in chemical synthesis. We are dedicated to being your trusted supplier of Potassium Tert-Butoxide, providing the quality and reliability that your critical processes demand.