Procuring 4-Bromo-2-methylbenzonitrile: A Chemist's Guide
As a chemist deeply involved in organic synthesis, procuring high-quality reagents like 4-Bromo-2-methylbenzonitrile (CAS: 67832-11-5) is fundamental to achieving successful outcomes. This aromatic nitrile is more than just a chemical compound; it’s a versatile building block that unlocks pathways to complex molecules for pharmaceuticals, agrochemicals, and advanced materials. Understanding its properties, preferred synthesis routes, and how to source it effectively is crucial.
Chemical Identity and Properties:
4-Bromo-2-methylbenzonitrile is an aryl nitrile characterized by its specific substitution pattern: a bromine atom at the 4-position and a methyl group at the 2-position of the benzene ring, with the nitrile group at the 1-position. Its molecular formula is C8H6BrN, and it typically appears as a white to off-white crystalline powder. Its melting point, usually in the range of 65-69°C, is a key indicator of its purity. For laboratory use, ensuring it dissolves adequately in common organic solvents like DMF or THF is important, as its water solubility is minimal.
Synthesis Considerations for Chemists:
From a synthetic chemist's viewpoint, 4-Bromo-2-methylbenzonitrile is a valuable starting material. Its aryl bromide moiety readily participates in palladium-catalyzed cross-coupling reactions (Suzuki, Sonogashira, Heck, etc.), allowing for the introduction of diverse carbon frameworks. The nitrile group can be transformed into amines, carboxylic acids, or amides, further expanding its synthetic utility. The methyl group offers a site for benzylic functionalization. When considering purchasing this compound, chemists often look for suppliers who can provide detailed information on its synthetic route, as this can sometimes hint at potential residual impurities that might affect downstream reactions. Manufacturers based in China often offer competitive pricing for this intermediate.
Purity and Quality Assurance:
In synthesis, purity is paramount. Even small amounts of impurities can derail complex reaction sequences or lead to unexpected byproducts. Therefore, when purchasing 4-Bromo-2-methylbenzonitrile, chemists prioritize suppliers who guarantee a high assay purity, typically 98% or higher. The accompanying Certificate of Analysis (CoA) is a critical document, detailing the purity, identification (e.g., via NMR or IR spectroscopy), and any significant impurities present. Reliable suppliers will have robust quality control measures in place.
Procurement for Research and Scale-Up:
For researchers, obtaining samples for initial studies is essential. For scale-up and production, securing a dependable supply chain is critical. When looking to buy, consider manufacturers who offer:
Ultimately, sourcing 4-Bromo-2-methylbenzonitrile from a reputable chemical supplier ensures that chemists have access to a reliable, high-quality building block, enabling them to focus on innovative synthesis and product development.
Chemical Identity and Properties:
4-Bromo-2-methylbenzonitrile is an aryl nitrile characterized by its specific substitution pattern: a bromine atom at the 4-position and a methyl group at the 2-position of the benzene ring, with the nitrile group at the 1-position. Its molecular formula is C8H6BrN, and it typically appears as a white to off-white crystalline powder. Its melting point, usually in the range of 65-69°C, is a key indicator of its purity. For laboratory use, ensuring it dissolves adequately in common organic solvents like DMF or THF is important, as its water solubility is minimal.
Synthesis Considerations for Chemists:
From a synthetic chemist's viewpoint, 4-Bromo-2-methylbenzonitrile is a valuable starting material. Its aryl bromide moiety readily participates in palladium-catalyzed cross-coupling reactions (Suzuki, Sonogashira, Heck, etc.), allowing for the introduction of diverse carbon frameworks. The nitrile group can be transformed into amines, carboxylic acids, or amides, further expanding its synthetic utility. The methyl group offers a site for benzylic functionalization. When considering purchasing this compound, chemists often look for suppliers who can provide detailed information on its synthetic route, as this can sometimes hint at potential residual impurities that might affect downstream reactions. Manufacturers based in China often offer competitive pricing for this intermediate.
Purity and Quality Assurance:
In synthesis, purity is paramount. Even small amounts of impurities can derail complex reaction sequences or lead to unexpected byproducts. Therefore, when purchasing 4-Bromo-2-methylbenzonitrile, chemists prioritize suppliers who guarantee a high assay purity, typically 98% or higher. The accompanying Certificate of Analysis (CoA) is a critical document, detailing the purity, identification (e.g., via NMR or IR spectroscopy), and any significant impurities present. Reliable suppliers will have robust quality control measures in place.
Procurement for Research and Scale-Up:
For researchers, obtaining samples for initial studies is essential. For scale-up and production, securing a dependable supply chain is critical. When looking to buy, consider manufacturers who offer:
- A clear and traceable synthetic process.
- Comprehensive analytical data (CoA, SDS).
- Flexible quantities, from gram-scale for R&D to kilogram-scale for pilot or commercial production.
- Competitive pricing and timely delivery.
Ultimately, sourcing 4-Bromo-2-methylbenzonitrile from a reputable chemical supplier ensures that chemists have access to a reliable, high-quality building block, enabling them to focus on innovative synthesis and product development.
Perspectives & Insights
Future Origin 2025
“Manufacturers based in China often offer competitive pricing for this intermediate.”
Core Analyst 01
“Even small amounts of impurities can derail complex reaction sequences or lead to unexpected byproducts.”
Silicon Seeker One
“Therefore, when purchasing 4-Bromo-2-methylbenzonitrile, chemists prioritize suppliers who guarantee a high assay purity, typically 98% or higher.”