For researchers and manufacturers engaged in peptide synthesis, the selection of the correct solid support is paramount. Among the various options available, Wang resins have established themselves as a reliable and versatile choice, particularly for Fmoc-based solid-phase peptide synthesis (SPPS). When you decide to buy Fmoc-amino acid Wang resins, understanding their specifications and how they impact your synthesis process is crucial. NINGBO INNO PHARMCHEM CO.,LTD., as a reputable supplier of peptide synthesis reagents, offers insights into making this critical decision.

Understanding Wang Resin Specifications

Wang resins are polystyrene-based supports functionalized with a p-alkoxybenzyl alcohol linker. This linker is specifically designed to cleave under acidic conditions, releasing the synthesized peptide acid. Key parameters to consider when purchasing Fmoc-amino acid Wang resins include:

  • Mesh Size: This refers to the particle size distribution of the resin beads. Common mesh sizes for peptide synthesis are 100-200 mesh and 200-400 mesh. Smaller mesh sizes (larger numbers) generally lead to better swelling and faster reaction kinetics, but can also increase back-pressure in automated synthesizers. For manual synthesis or when using automated synthesizers that can handle it, finer mesh sizes can be advantageous.
  • Crosslinking: Typically, Wang resins are crosslinked with 1% divinylbenzene (DVB). Higher crosslinking can improve solvent resistance but may reduce swelling. The standard 1% DVB offers a good balance for most SPPS applications.
  • Substitution Level: This indicates the capacity of the resin, usually expressed in millimoles of amino acid that can be loaded per gram of resin (mmol/g). Typical substitution levels for Fmoc-amino acid Wang resins range from 0.3 to 1.0 mmol/g. A higher substitution level allows for more efficient synthesis with less resin, but can sometimes lead to side reactions or incomplete coupling if not managed carefully. For custom peptide synthesis, consulting with your manufacturer about the ideal substitution level for your specific peptide sequence is recommended.

Why Choose NINGBO INNO PHARMCHEM CO.,LTD. as Your Wang Resin Supplier?

As a dedicated manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. focuses on providing high-purity and consistent quality peptide synthesis reagents. When you partner with us to buy Fmoc-Ala-Wang Resin or other Fmoc-amino acid resins, you benefit from:

  • Quality Assurance: Our manufacturing processes adhere to strict quality control standards, ensuring you receive resins that meet your research and production demands.
  • Competitive Pricing: By sourcing directly from our facility, you can achieve cost-effective peptide synthesis without compromising on the quality of your starting materials.
  • Technical Support: Our team of experts is available to assist you in selecting the most suitable resin and optimizing your synthesis protocols.

The choice of Fmoc-Ala-Wang resin is a critical step in ensuring the success of your peptide synthesis projects. By understanding the key specifications and partnering with a reliable manufacturer and supplier like NINGBO INNO PHARMCHEM CO.,LTD., you can streamline your workflow and achieve high-quality peptide products efficiently. If you are looking to buy Fmoc-Ala-Wang Resin or require custom peptide synthesis solutions, reach out to us for a quote and expert consultation.