Diphenyl chlorophosphate (CAS 2524-64-3) is a compound that plays a pivotal role in organic chemistry, primarily due to its potent phosphorylating capabilities. Understanding its precise chemical properties and the various methods employed for its synthesis is key to its effective utilization in diverse industrial applications, from pharmaceutical intermediates to agrochemical development. This article provides an in-depth look at the chemical profile and synthesis pathways of this important intermediate.

Chemically, Diphenyl chlorophosphate is described as a transparent, colorless to light yellow liquid. It possesses a pungent odor and has a density of 1.296 g/mL at 25°C, making it denser than water. Its high boiling point, 314-316°C at 272 mmHg, indicates its stability at elevated temperatures under specific conditions. A critical aspect of its Diphenyl chlorophosphate properties is its moisture sensitivity; it may decompose upon contact with water, necessitating careful handling and storage in dry environments, often under an inert atmosphere. It is also incompatible with strong bases and oxidizing agents, which can lead to vigorous reactions.

The synthesis of Diphenyl chlorophosphate can be achieved through several routes, with the reaction between phenol and phosphorus trichloride being a common industrial method. In this process, phenol and phosphorus trichloride are reacted at elevated temperatures (around 140°C) until the phenol content drops below a specified threshold. The resulting product is then purified through vacuum distillation. Another method involves the reaction of diphenyl phosphate with a chlorinating agent such as bis(trichloromethyl) carbonate in a suitable solvent. Understanding these synthesis methods helps in appreciating the underlying chemistry and the factors influencing product purity and yield, which in turn affect the overall Diphenyl chlorophosphate price.

Safety is a paramount concern when handling Diphenyl chlorophosphate. Due to its corrosive nature and potential to cause severe irritation to skin, eyes, and mucous membranes, appropriate personal protective equipment (PPE) is mandatory. Its hazard symbols often include GHS05 and GHS07, indicating corrosive and irritant properties, with a signal word of 'Danger'. Hazard statements like H314 (Causes severe skin burns and eye damage) and H318 (Causes serious eye damage) are commonly associated with it. Precautionary statements such as P280 (Wear protective gloves/protective clothing/eye protection/face protection) and P301+P330+P331 (IF SWALLOWED: Rinse mouth. Do NOT induce vomiting) are critical for safe handling. The availability of detailed safety data sheets (SDS) from reputable Diphenyl chlorophosphate suppliers is essential.

The utility of Diphenyl chlorophosphate extends to its role as a key intermediate. For example, it can be used in the synthesis of methadone, an important opioid used in pain management and opioid addiction treatment. It also finds applications in controlling seedling grasses in turf and in various condensation reactions that lead to the formation of important organic molecules. The continuous exploration of new Diphenyl chlorophosphate applications drives demand and innovation in its production and supply.

In conclusion, Diphenyl chlorophosphate is a chemically robust and highly functional compound. Its well-defined Diphenyl chlorophosphate properties, coupled with established synthesis methods, make it a reliable tool for chemists. When considering Diphenyl chlorophosphate for purchase, it is vital to partner with suppliers who not only offer competitive pricing but also provide comprehensive technical and safety information, ensuring its effective and safe integration into various chemical processes.