The art and science of organic synthesis are built upon a foundation of versatile building blocks that enable chemists to construct intricate molecular architectures. 2-Fluorothiophenol (CAS 2557-78-0) is one such indispensable reagent, prized for its unique chemical reactivity and its role in facilitating a wide array of synthetic transformations. For chemists engaged in cutting-edge research and development, understanding how to effectively utilize and source this compound is crucial.

The Chemistry of 2-Fluorothiophenol

2-Fluorothiophenol, with its molecular formula C6H5FS and molecular weight of 128.17, presents a fascinating combination of functional groups. The presence of a fluorine atom on the benzene ring, adjacent to the thiol (-SH) group, influences the electron density and reactivity of the molecule. This ortho-fluorination can direct subsequent reactions and alter the physical properties, such as boiling point (61-62 °C/35 mmHg) and solubility, compared to unsubstituted thiophenol. Its typical appearance as a light yellow liquid with a purity assay of 98% min underscores its suitability for demanding synthetic applications.

Key Synthetic Applications and Strategies

The versatility of 2-Fluorothiophenol stems from its dual functionality. The thiol group can readily undergo nucleophilic substitution, oxidation, and addition reactions, while the activated aromatic ring is amenable to electrophilic aromatic substitution and metal-catalyzed cross-coupling reactions. Chemists often leverage these properties to:

  • Introduce Fluorine into Organic Molecules: The ortho-fluoro substituent can impart beneficial properties to target molecules, such as increased metabolic stability, altered lipophilicity, and modulated binding affinities, which are particularly important in medicinal chemistry.
  • Synthesize Sulfur-Containing Heterocycles: The thiol group serves as a key component in cyclization reactions, leading to the formation of various sulfur-containing heterocycles, which are common motifs in pharmaceuticals and agrochemicals.
  • Act as a Ligand or Catalyst Component: Thiophenols can sometimes act as ligands in organometallic catalysis or as precursors to more complex catalytic systems.

When planning synthetic routes, researchers often need to buy 2-fluorothiophenol for specific steps where these functionalities are critical. Understanding the exact requirements for purity and quantity is paramount when placing an order with a chemical supplier.

Procuring 2-Fluorothiophenol from Reliable Sources

For consistent and successful synthesis, obtaining 2-Fluorothiophenol from a trusted manufacturer is paramount. Suppliers like NINGBO INNO PHARMCHEM CO.,LTD. are recognized for providing high-quality chemical intermediates with accurate specifications and competitive pricing. When you seek to purchase 2-fluorothiophenol, inquire about their product’s CAS number (2557-78-0), assay, and any available technical data or safety information. Their commitment to quality assurance ensures that your R&D efforts are supported by dependable materials, making the entire process of buying chemicals more efficient and productive.

By understanding the chemical characteristics and synthetic utility of 2-Fluorothiophenol, chemists can strategically integrate it into their reaction schemes, pushing the boundaries of molecular innovation. Partnering with a reputable chemical supplier ensures that the journey from conception to synthesis is as smooth and effective as possible.