In the intricate world of chemical synthesis, the selection of the right intermediate can dramatically influence the outcome of a reaction, the efficiency of a process, and the final properties of a compound. 4-Chloro-2-(trifluoromethyl)benzonitrile (CAS: 320-41-2) is a prime example of a high-value intermediate that offers significant synthetic advantages, particularly for those working in the fine chemical, pharmaceutical, and agrochemical industries.

Chemical Profile and Properties

4-Chloro-2-(trifluoromethyl)benzonitrile is characterized by its distinct molecular structure: a benzonitrile core substituted with a chlorine atom at the 4-position and a trifluoromethyl group at the 2-position. This specific arrangement imbues the molecule with unique reactivity:

  • Chemical Name: 4-Chloro-2-(trifluoromethyl)benzonitrile
  • CAS Number: 320-41-2
  • Molecular Formula: C₈H₃ClF₃N
  • Molecular Weight: 205.56 g/mol
  • Appearance: Light brown to brown liquid
  • Purity: Typically ≥98.0%
  • Key Functional Groups: Nitrile (CN), Chloro (Cl), Trifluoromethyl (CF₃)

These features make it an excellent substrate for various synthetic transformations. The nitrile group can be hydrolyzed to a carboxylic acid, reduced to an amine, or participate in cycloaddition reactions. The trifluoromethyl group, as mentioned previously, is known to enhance lipophilicity and metabolic stability in bioactive molecules. The chlorine atom is a versatile leaving group, amenable to nucleophilic aromatic substitution or transition-metal-catalyzed cross-coupling reactions such as Suzuki, Heck, or Buchwald-Hartwig couplings.

Applications and Synthetic Utility

The primary role of 4-Chloro-2-(trifluoromethyl)benzonitrile is as an intermediate in the synthesis of more complex organic molecules. Its strategic use can lead to:

  • Pharmaceutical Intermediates: It serves as a building block for synthesizing active pharmaceutical ingredients (APIs) with tailored pharmacological properties.
  • Agrochemical Synthesis: It contributes to the development of new crop protection chemicals, offering enhanced efficacy and targeted action.
  • Specialty Chemicals: Its unique structure makes it valuable in the creation of various fine chemicals for specialized applications.

For any chemist or procurement manager looking to buy this compound, understanding its potential applications is key to assessing its value for specific projects. Reliable sourcing is paramount, and as a dedicated manufacturer and supplier, we ensure high-purity material is available to meet demand. We offer competitive pricing and ensure consistent quality, making us an ideal partner for your chemical needs.

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