1,3-Diiodobenzene, commonly known as m-Diiodobenzene and identified by CAS number 626-00-6, is a fascinating aromatic organic compound that holds significant importance in synthetic chemistry. Its molecular structure, featuring two iodine atoms strategically placed on a benzene ring at the meta positions, grants it a unique reactivity profile, making it a versatile tool for chemists. Understanding these chemical properties is fundamental to unlocking its potential in various industrial and research applications. NINGBO INNO PHARMCHEM CO.,LTD. is a key provider of this essential chemical.

The chemical properties of 1,3-diiodobenzene are largely dictated by the presence of the carbon-iodine bonds. These bonds are relatively weak compared to carbon-chlorine or carbon-bromine bonds, making the iodine atoms excellent leaving groups in nucleophilic substitution reactions and highly susceptible to participation in metal-catalyzed coupling reactions. This enhanced reactivity is precisely why it is so valued as an m-diiodobenzene synthesis intermediate. Its molecular formula, C6H4I2, reflects its composition, and its molecular weight is approximately 329.91 g/mol. The compound typically appears as a yellow to beige crystalline powder or solid, with a melting point in the range of 34-37°C.

One of the most prominent applications of 1,3-diiodobenzene lies in its use as a building block for creating more complex organic molecules. It readily participates in various cross-coupling reactions, such as the Suzuki-Miyaura coupling, Heck reaction, and Sonogashira coupling. These reactions are cornerstone methodologies in modern organic synthesis, enabling the formation of new carbon-carbon bonds. For example, its reaction with aryl boronic acids in the presence of a palladium catalyst allows for the construction of biaryl compounds, which are common motifs in pharmaceuticals and organic electronic materials. This versatility makes it an indispensable tool for those looking for organic synthesis building blocks.

In the pharmaceutical industry, 1,3-diiodobenzene serves as a precursor for synthesizing a wide range of active pharmaceutical ingredients (APIs) and intermediates. Its ability to be selectively functionalized allows chemists to introduce iodine atoms or subsequently replace them with other desired groups, facilitating the creation of intricate molecular structures with specific biological activities. Researchers often buy m-diiodobenzene from reliable manufacturers to ensure the consistency and purity needed for complex drug synthesis pathways. NINGBO INNO PHARMCHEM CO.,LTD. ensures that their m-diiodobenzene meets the high standards required by the pharmaceutical sector.

Furthermore, the agrochemical sector utilizes 1,3-diiodobenzene in the synthesis of various crop protection agents. Its integration into pesticide or herbicide molecules can impart specific properties that enhance efficacy or environmental compatibility. As industries increasingly demand more sophisticated and targeted agrochemical solutions, the role of versatile intermediates like m-diiodobenzene becomes even more critical. This highlights the importance of having access to dependable chemical intermediates from suppliers like NINGBO INNO PHARMCHEM CO.,LTD.

The chemical properties of 1,3-diiodobenzene make it a powerful reagent for advanced synthetic chemistry. Its participation in key coupling reactions and its role as a precursor in pharmaceuticals and agrochemicals solidify its position as a vital component in the chemical industry. For researchers and manufacturers seeking to advance their projects, understanding and utilizing the capabilities of this compound, sourced from trusted providers, is a strategic advantage.