NINGBO INNO PHARMCHEM CO.,LTD. is a premier supplier of specialized chemical compounds, including Tosylmethyl Isocyanide (TosMIC), CAS number 36635-61-7. This compound is highly regarded for its unique chemical properties and diverse applications, making it a cornerstone reagent in many areas of chemical research and industrial processes. Understanding these properties is crucial for chemists looking to effectively utilize TosMIC in their projects.

Tosylmethyl Isocyanide, often abbreviated as TosMIC, typically appears as a white to pale yellow crystalline solid. It possesses a characteristic melting point range, often cited between 109-113 °C, indicating a stable solid form under ambient conditions. Its solubility profile is also noteworthy; it dissolves readily in polar aprotic solvents such as Tetrahydrofuran (THF), Dimethylformamide (DMF), and Dimethyl sulfoxide (DMSO), while showing limited solubility in alcohols. Proper storage, typically under inert gas at cool temperatures (2-8°C) and away from moisture, is recommended to maintain its integrity and shelf life of approximately 12 months.

The chemical reactivity of TosMIC stems from its dual functionality: the electron-withdrawing tosyl group and the highly reactive isocyanide group. This combination makes it a potent synthon in organic synthesis. As previously discussed, its pivotal role in the Van Leusen reaction for nitrile synthesis and its application in the preparation of heterocycles like oxazoles, imidazoles, and pyrroles are well-documented. These transformations are fundamental for creating complex molecular structures, including those used as pharmaceutical intermediates and in medicinal chemistry.

Beyond these primary applications, the tosMIC uses in organic synthesis are continually being explored. Its participation in multicomponent reactions, such as the Ugi and Passerini reactions, further highlights its versatility in rapidly assembling complex molecular frameworks. This makes TosMIC a valuable tool for combinatorial chemistry and the discovery of new bioactive compounds. For those who wish to buy TosMIC, NINGBO INNO PHARMCHEM CO.,LTD. ensures access to a high-purity product, critical for achieving reliable and efficient reaction outcomes.

At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to providing researchers and industries with the finest chemical reagents. Our Tosylmethyl Isocyanide is manufactured to exacting standards, ensuring its suitability for demanding applications. By understanding and harnessing the chemical properties of TosMIC, chemists can unlock its full potential, driving innovation in areas ranging from pharmaceutical development to material science. We encourage you to explore the multifaceted applications of this exceptional chemical compound.