The landscape of chemical synthesis is constantly evolving, driven by the need for more efficient and precise methods. Within this field, intermediates like 2-Chloro-3,5-dibromopyridine (CAS: 40360-47-2) play a fundamental role, acting as essential precursors for a wide array of complex organic molecules. This article aims to shed light on the chemical and physical characteristics of this compound, its synthesis, and its significant applications, particularly highlighting its availability from leading suppliers.

Chemical Identity and Properties

2-Chloro-3,5-dibromopyridine, also known by its IUPAC name 3,5-dibromo-2-chloropyridine, is a halogenated pyridine derivative with the molecular formula C5H2Br2ClN. It possesses a molecular weight of approximately 271.34 g/mol. As a white to off-white crystalline solid, its physical form is stable and easy to handle. Key physical properties include a density of 2.1 ± 0.1 g/cm³, a boiling point of 257.1 ± 35.0 °C at 760 mmHg, and a melting point range of 42-44ºC. These characteristics indicate its suitability for use in various chemical processes, provided appropriate handling procedures are followed. Its high purity, typically ≥98.0% assay, is a critical factor for its adoption in sensitive synthesis routes.

Synthesis Strategies and Manufacturing Insights

The production of 2-Chloro-3,5-dibromopyridine often involves the selective halogenation of pyridine derivatives. Advanced synthetic methodologies are employed to ensure regioselectivity and high yields. For businesses seeking to purchase this intermediate, understanding the manufacturing capabilities of suppliers is important. China has established itself as a key player in the global fine chemical market, with numerous manufacturers specializing in the production of halogenated pyridines. These manufacturers adhere to stringent quality control measures, ensuring that products meet international standards. When sourcing from a China supplier, expect efficient logistics and competitive pricing for bulk orders, making it an attractive option for procurement professionals.

Diverse Applications of 2-Chloro-3,5-dibromopyridine

The multifaceted nature of 2-Chloro-3,5-dibromopyridine leads to its application in several high-impact fields:

  • Organic Synthesis: It serves as a cornerstone building block for organic chemists, facilitating the construction of complex molecules through various reactions such as cross-coupling and nucleophilic substitutions. Its utility in creating diverse chemical libraries is invaluable for discovery research.
  • Pharmaceutical Intermediate: The compound is frequently used in the early stages of drug discovery and development. Its incorporation into candidate molecules can influence their pharmacological properties, making it a sought-after intermediate for pharmaceutical companies. Procuring this via a dedicated supplier ensures consistent quality for API synthesis.
  • Agrochemical Synthesis: In the agricultural sector, 2-Chloro-3,5-dibromopyridine is instrumental in the synthesis of advanced agrochemicals, including novel pesticides and herbicides. Its targeted reactivity helps in developing crop protection solutions with improved efficacy and safety profiles.

Choosing a Reliable Supplier

When sourcing 2-Chloro-3,5-dibromopyridine, it is essential to partner with a reliable manufacturer or supplier. Reputable companies in China offer not only high-purity products but also robust support, including technical documentation and responsive customer service. For any R&D scientist or procurement manager, securing a consistent supply of this critical intermediate is vital for project success. Many manufacturers provide product quotes upon inquiry, facilitating the procurement process for bulk purchases.

In summary, 2-Chloro-3,5-dibromopyridine is a highly valuable chemical intermediate, underpinning advancements in pharmaceuticals, agrochemicals, and organic synthesis. Its precise chemical properties, coupled with its availability from proficient manufacturers, solidify its importance in the modern chemical industry.