At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to supplying the foundational materials that drive scientific progress. Fmoc-D-Phe-OH, also known as N-Fmoc-D-phenylalanine, is a prime example of such a critical reagent, widely utilized in the field of peptide synthesis.

Fmoc-D-Phe-OH, with CAS number 86123-10-6, is the D-enantiomer of phenylalanine, a common amino acid. Phenylalanine itself is an aromatic amino acid that plays a significant role in protein structure and function. However, the incorporation of D-amino acids, like Fmoc-D-Phe-OH, into peptide sequences can impart unique properties. These include increased resistance to proteolytic degradation and altered receptor binding profiles, which are highly sought after in the development of peptide-based pharmaceuticals.

The Fmoc protecting group attached to the amino terminus of D-phenylalanine is crucial for its application in solid-phase peptide synthesis (SPPS). This protecting group allows for the controlled, sequential addition of amino acids to a growing peptide chain. The Fmoc group is stable under the acidic conditions often used in SPPS but can be readily removed using a mild base, such as piperidine, regenerating the free amine for the next coupling step. This orthogonality is key to efficient peptide assembly.

Key specifications for Fmoc-D-Phe-OH typically include:

  • Molecular Formula: C24H21NO4
  • Molecular Weight: Approximately 387.4 g/mol
  • Appearance: Usually a white to off-white solid.
  • Purity: Typically specified at 98% or higher via HPLC.

The applications of Fmoc-D-Phe-OH are diverse and significant:

  • Peptide Drug Development: Many therapeutic peptides incorporate D-amino acids to improve stability and bioavailability. Fmoc-D-Phe-OH is a common building block for creating such peptides.
  • Biochemical Research: It is used in laboratories to synthesize peptides for studying enzyme mechanisms, protein-protein interactions, and receptor binding.
  • Combinatorial Chemistry: Its use in library synthesis allows researchers to rapidly generate a large number of peptide analogs for screening biological activity.

NINGBO INNO PHARMCHEM CO.,LTD. understands the importance of reliable sourcing for these essential reagents. By providing high-quality Fmoc-D-Phe-OH, we support researchers in their pursuit of novel discoveries and the development of advanced peptide-based technologies.