For research scientists and laboratory managers, the ability to procure essential chemical reagents efficiently and effectively is fundamental to the success of experimental work. Mesitylenesulfonyl chloride (CAS 773-64-8), also known as 2,4,6-Trimethylbenzenesulfonyl Chloride, is a widely used compound in organic synthesis. This guide aims to provide valuable insights for anyone looking to buy this critical reagent for their laboratory needs.

Understanding Mesitylenesulfonyl Chloride

Mesitylenesulfonyl chloride is a white crystalline solid prized for its role as a sulfonylating agent. Its chemical structure, featuring a sulfonyl chloride group attached to a bulky mesitylene ring, provides specific reactivity patterns that are advantageous in many synthetic procedures. Its primary function is to introduce the mesitylenesulfonyl group (-SO2Mes) into other molecules, often acting as an electrophile.

Key Laboratory Applications

In a research setting, mesitylenesulfonyl chloride is indispensable for several key applications:

  • Synthesis of Sulfonamides and Sulfonates: It readily reacts with primary and secondary amines to form sulfonamides, and with alcohols to form sulfonate esters. These functional groups are prevalent in biologically active molecules and are important intermediates in further transformations. Researchers often buy this compound to synthesize custom derivatives for drug discovery or material science studies.
  • Peptide Synthesis: In specialized peptide chemistry, sulfonyl chlorides can be used to activate carboxyl groups or to form specific linkages.
  • Derivatization Agent: It can be used to derivatize certain functional groups to improve their detectability or separability in analytical techniques like chromatography.
  • Research into New Materials: Its utility extends to the creation of novel polymers and functional materials where the sulfonyl group can impart desired properties.

Tips for Buying Mesitylenesulfonyl Chloride

When your laboratory requires mesitylenesulfonyl chloride, consider these essential procurement tips:

  • Purity Matters: For most research applications, high purity (e.g., ≥98% by GC or HPLC) is non-negotiable. Always check the product specifications and request a Certificate of Analysis (CoA) to confirm purity and identify any potential impurities that might affect your experiments.
  • Supplier Selection: Look for reputable chemical suppliers and manufacturers who specialize in laboratory reagents. Consider companies that offer detailed product information, fast shipping, and responsive customer support. For bulk lab needs, inquire about potential discounts.
  • Safety and Handling: Mesitylenesulfonyl chloride is a corrosive material. Always consult the Safety Data Sheet (SDS) before handling. Ensure appropriate personal protective equipment (PPE) is used, and that it is stored correctly, typically in a cool, dry place away from moisture and incompatible substances.
  • Quantity: Purchase only the quantity needed to avoid degradation over time. Many suppliers offer various pack sizes, from grams to kilograms, catering to different research scales.

By adhering to these guidelines, researchers can confidently buy mesitylenesulfonyl chloride, ensuring the quality and success of their laboratory work. A trusted supplier makes all the difference.