The pharmaceutical industry relies heavily on efficient and selective synthetic routes to produce Active Pharmaceutical Ingredients (APIs) and their intermediates. In this demanding landscape, hypervalent iodine reagents have emerged as indispensable tools, offering unique reactivity profiles. Iodobenzene Diacetate (CAS 3240-34-4), commonly known as PIDA or DAIB, is a prime example of such a reagent, widely utilized for its oxidizing capabilities in synthesizing complex pharmaceutical building blocks.

PIDA's Role in Pharmaceutical Synthesis

As a powerful oxidizing agent, Iodobenzene Diacetate facilitates critical transformations that are often challenging with other reagents. Its applications in pharmaceutical intermediate synthesis include:

  • Oxidation of Alcohols: PIDA efficiently converts primary and secondary alcohols into aldehydes and ketones, respectively, crucial steps in many API syntheses.
  • Functionalization of Unsaturated Bonds: It can be used for oxidative cleavage of double bonds or to introduce oxygen-containing functional groups, enabling the construction of complex carbon skeletons.
  • Rearrangement Reactions: PIDA is instrumental in promoting various rearrangement reactions, such as the Hofmann rearrangement, which is vital for introducing amine functionalities into molecules.
  • C-H Activation and Functionalization: Emerging research highlights PIDA's role in direct C-H functionalization, a highly sought-after methodology for streamlining synthetic pathways.

The advantage of using PIDA lies in its selectivity and the often milder reaction conditions it permits, which are essential when dealing with sensitive functional groups common in pharmaceutical molecules. This selectivity minimizes the formation of unwanted byproducts, leading to higher yields and purer intermediates.

Procuring High-Quality Iodobenzene Diacetate

For pharmaceutical companies and contract manufacturing organizations (CMOs), sourcing PIDA requires a focus on quality, reliability, and cost-effectiveness. When looking to buy Iodobenzene Diacetate, it is essential to partner with a reputable manufacturer. NINGBO INNO PHARMCHEM CO.,LTD. offers PIDA with guaranteed high purity (≥98.5%), ensuring it meets the stringent requirements of pharmaceutical synthesis. As a leading chemical supplier based in China, we provide:

  • Consistent Supply: We maintain robust production capabilities to ensure a steady supply of PIDA, critical for uninterrupted manufacturing processes.
  • Competitive Manufacturer Pricing: Direct sourcing from us offers significant cost advantages, helping to reduce overall production expenses for your pharmaceutical intermediates.
  • Technical Data and Support: We provide comprehensive Technical Data Sheets (TDS) and Safety Data Sheets (SDS), along with technical support to assist with your application queries.

By choosing NINGBO INNO PHARMCHEM CO.,LTD. as your supplier for Iodobenzene Diacetate, you are investing in a reliable partnership that supports your critical drug development and manufacturing pipelines. We are committed to delivering excellence in chemical supply, enabling innovation in the pharmaceutical sector. Inquire today for a price quote and sample of our high-grade PIDA.