For chemists and engineers involved in chemical manufacturing and research, a deep understanding of reagent properties is fundamental to successful synthesis and product development. Isobutyric Anhydride (CAS 97-72-3) is a compound that merits close attention due to its specific physical and chemical characteristics, which dictate its broad applicability. As a key acylating agent, its properties directly influence reaction outcomes, efficiency, and the safety protocols required during handling and storage.

Key Physical Properties of Isobutyric Anhydride

Isobutyric Anhydride presents itself with distinct physical attributes that are important for its identification and handling:

  • Appearance: It is typically observed as a colorless liquid. This visual characteristic is an initial indicator of its purity.
  • Molecular Formula: C8H14O3. This formula defines its elemental composition.
  • Molecular Weight: Approximately 158.20 g/mol. This value is critical for stoichiometric calculations in synthesis.
  • Boiling Point: Around 182°C (lit.). This property is important for distillation and purification processes.
  • Melting Point: Approximately -56°C (lit.). Its low melting point means it remains liquid under standard laboratory conditions.
  • Density: Around 0.954 g/mL at 20°C. This allows for volume-to-mass conversions.
  • Solubility: It is noted to be soluble in ether and reacts with water (hydrolyzes). This reactivity with water is a key consideration for storage and handling.

Crucial Chemical Properties and Reactivity

The chemical behavior of Isobutyric Anhydride is what makes it so valuable:

  • Acylating Agent: Its primary function is as an acylating agent, meaning it readily donates an acyl group (isobutyryl group) to other molecules. This is achieved through esterification and amidation reactions.
  • Reactivity: It is a reactive compound, particularly susceptible to hydrolysis in the presence of moisture, reverting to isobutyric acid. This necessitates storage in tightly sealed containers and in dry environments.
  • Hazard Classification: It is classified as a dangerous good for transport, often associated with hazards such as severe skin burns and eye damage, and toxicity if inhaled or swallowed, depending on concentration and exposure. Safe handling practices and appropriate personal protective equipment (PPE) are therefore mandatory.

Importance of Purity and Sourcing

For any chemical synthesis, particularly in sectors like pharmaceuticals and agrochemicals, the purity of Isobutyric Anhydride is paramount. Impurities can lead to side reactions, reduced yields, and contamination of the final product. Therefore, when you buy Isobutyric Anhydride, it is essential to source it from reputable manufacturers and suppliers who provide detailed specifications and Certificates of Analysis (CoAs). Companies specializing in fine chemicals, including manufacturers in China, often offer high-purity grades suitable for demanding applications.

Conclusion

Understanding the physical and chemical properties of Isobutyric Anhydride (CAS 97-72-3) is fundamental for its effective and safe utilization in chemical synthesis. Its liquid form, reactivity as an acylating agent, and need for careful handling highlight the importance of sourcing from reliable suppliers who can guarantee purity and provide necessary technical information. For professionals seeking this critical intermediate, focusing on these properties will ensure successful outcomes in their manufacturing and research endeavors.