Hexamethylphosphoramide (HMPA), identified by its CAS No. 680-31-9, is a chemical compound with a unique set of properties that dictate its diverse industrial applications. For professionals in the chemical industry, from procurement specialists to R&D scientists, a thorough understanding of HMPA's chemical characteristics and safe handling procedures is fundamental. This overview aims to provide essential information for those looking to purchase or utilize this versatile compound.

Physical and Chemical Characteristics of HMPA

Hexamethylphosphoramide is typically described as a colorless liquid, often possessing a spicy or aromatic odor. Its molecular formula is C6H18N3OP, with a molecular weight of approximately 179.2 g/mol. A key characteristic is its high polarity and aprotic nature, which makes it an excellent solvent for a wide range of organic and inorganic compounds, as well as various polymer materials. Its miscibility with water and common organic solvents like methanol, ether, and benzene further enhances its utility in chemical processes. The relatively high boiling point (around 230-232 °C) allows for reactions to be conducted at elevated temperatures without significant solvent loss.

Key properties include:

  • Appearance: Colorless liquid
  • Odor: Spicy or aromatic
  • Solubility: Miscible with water, alcohols, ethers, and other polar organic solvents; slightly soluble in methanol; insoluble in saturated alkanes.
  • Boiling Point: Approximately 230-232 °C
  • Density: Around 1.03 g/mL at 25 °C
  • Stability: Generally stable but incompatible with strong acids and oxidizing agents.

Manufacturers producing HMPA often achieve purities exceeding 99.0%, ensuring its suitability for sensitive chemical synthesis and formulation work. When procuring HMPA, verifying the purity and stability from a reputable supplier is crucial.

Safe Handling and Storage Practices

Given its classification as a toxic substance and potential carcinogen, the safe handling of Hexamethylphosphoramide is of utmost importance. Standard laboratory and industrial safety protocols must be rigorously followed. This includes working in a well-ventilated area, preferably under a fume hood, and always wearing appropriate personal protective equipment (PPE). Essential PPE includes chemical-resistant gloves (e.g., nitrile or neoprene), safety goggles or a face shield to prevent eye contact, and protective clothing to avoid skin exposure. Containers should be kept tightly sealed to prevent moisture absorption, which can degrade the product, and stored in a cool, dry place away from incompatible materials like strong acids and oxidizers.

Procuring Hexamethylphosphoramide

For businesses looking to purchase HMPTA, it is advisable to partner with experienced chemical suppliers and manufacturers who can guarantee product quality and provide comprehensive safety documentation, such as the Safety Data Sheet (SDS). Understanding the specific grade and purity required for your intended application will guide your selection process.

In summary, Hexamethylphosphoramide is a valuable chemical with distinct properties that lend themselves to critical industrial applications. By understanding its chemical characteristics and adhering to strict safety protocols during handling and storage, professionals can effectively and safely utilize this important compound.