In the intricate world of pharmaceutical research and development, sourcing the right chemical intermediates is paramount to success. One such crucial compound that frequently appears in the synthesis pathways of novel drugs is 4-Bromo-1-fluoro-2-nitrobenzene. Understanding its properties, applications, and where to buy it from reputable suppliers can significantly streamline your R&D process.

What is 4-Bromo-1-fluoro-2-nitrobenzene?

This aromatic organic compound, with the CAS number 364-73-8 and molecular formula C6H3BrFNO2, is characterized by the presence of bromine, fluorine, and a nitro group on a benzene ring. This unique combination of functional groups imparts specific reactivity, making it an invaluable building block in a wide array of organic synthesis reactions. Its typical appearance is a light yellow liquid, with a melting point around 18-19 °C, indicating it's often handled as a liquid at room temperature.

Why is it Important for Pharmaceutical Synthesis?

The true value of 4-Bromo-1-fluoro-2-nitrobenzene lies in its versatility. Researchers often leverage the bromine atom for palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings, which are fundamental for constructing complex biaryl structures commonly found in many drug molecules. The fluorine atom can introduce favorable pharmacokinetic properties to drug candidates, influencing their metabolic stability and bioavailability. Furthermore, the nitro group can be readily reduced to an amine, opening up another avenue for functionalization and the creation of diverse molecular scaffolds. This makes it a cornerstone for developing new pharmaceuticals, from experimental compounds to established active pharmaceutical ingredients (APIs).

Applications Beyond Pharmaceuticals

While its role in drug discovery is significant, 4-Bromo-1-fluoro-2-nitrobenzene is also a key intermediate in the synthesis of agrochemicals. Its reactivity allows for the creation of potent herbicides, insecticides, and fungicides that are essential for modern agriculture. Beyond life sciences, this compound finds application in the development of specialty chemicals and advanced materials where its unique structural features can be exploited to achieve desired performance characteristics.

Sourcing High-Quality 4-Bromo-1-fluoro-2-nitrobenzene

When seeking to buy 4-Bromo-1-fluoro-2-nitrobenzene for your research or production needs, it is crucial to partner with a reliable manufacturer. The purity of intermediates directly impacts the success and efficiency of subsequent reactions. Look for suppliers who can guarantee a high assay, typically ≥98.0% or higher, and provide comprehensive technical documentation, such as Certificates of Analysis (CoA). As a dedicated manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. offers high-purity 4-Bromo-1-fluoro-2-nitrobenzene, ensuring consistent quality and a stable supply chain. Understanding the price of this critical intermediate is also a key consideration for budget planning. Engaging directly with a primary supplier can often provide more competitive pricing and ensure product authenticity.

In conclusion, 4-Bromo-1-fluoro-2-nitrobenzene is more than just a chemical compound; it's an enabler of scientific advancement. For any R&D scientist or procurement manager looking to innovate in pharmaceuticals, agrochemicals, or material science, securing a dependable source for this versatile intermediate is a strategic move. Explore your options and partner with a trusted manufacturer to accelerate your next breakthrough.