In the realm of organic chemistry, the choice of reducing agent can significantly impact the success of a synthesis. Among the most commonly used are Lithium Aluminium Hydride (LiAlH4) and Sodium Borohydride (NaBH4). While both are hydride sources, their reactivity profiles and applications differ considerably. Understanding these differences is crucial for any chemist looking to efficiently transform carbonyl compounds and other functional groups. As a prominent manufacturer and supplier of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. provides both these vital reagents and shares insights to help you make informed decisions.

Lithium Aluminium Hydride (LiAlH4): The Powerhouse

LiAlH4 is a significantly stronger reducing agent than NaBH4. Its aluminum-hydrogen bonds are more polar, allowing for a more potent delivery of hydride ions. This strength enables LiAlH4 to reduce a wider array of functional groups, including:

  • Aldehydes and ketones (like NaBH4)
  • Carboxylic acids
  • Esters
  • Amides
  • Nitriles
  • Acid halides

However, this high reactivity comes with a caveat: LiAlH4 reacts violently with protic solvents like water and alcohols, necessitating the use of anhydrous solvents such as diethyl ether or tetrahydrofuran (THF). If you need to reduce functional groups beyond simple aldehydes and ketones, LiAlH4 is your reagent of choice. To buy LiAlH4 for demanding applications, ensure you source it from a reliable LiAlH4 supplier in China like NINGBO INNO PHARMCHEM.

Sodium Borohydride (NaBH4): The Selective Agent

NaBH4, in contrast, is a milder reducing agent. It is primarily used for the selective reduction of aldehydes and ketones to their corresponding alcohols. Its weaker reactivity makes it compatible with protic solvents, simplifying reaction setup and workup. NaBH4 typically does not reduce esters, carboxylic acids, amides, or nitriles under standard conditions. This selectivity can be highly advantageous when a molecule contains multiple reducible functional groups, and you only wish to target the aldehyde or ketone.

Choosing the Right Reagent: Key Considerations

When deciding between LiAlH4 and NaBH4, consider the following:

  • Functional Group Compatibility: If you need to reduce carboxylic acids, esters, amides, or nitriles, LiAlH4 is necessary. For selective reduction of aldehydes and ketones, NaBH4 is often preferred.
  • Reaction Conditions: LiAlH4 requires strictly anhydrous conditions, while NaBH4 can be used in protic solvents, offering greater ease of use.
  • Safety: LiAlH4 demands more stringent safety protocols due to its vigorous reaction with moisture.
  • Cost and Availability: Both reagents are widely available, but specific grades and quantities can impact pricing. As a trusted manufacturer, we offer competitive NaBH4 and LiAlH4 prices.

Partner with NINGBO INNO PHARMCHEM

Whether your synthesis demands the robust power of LiAlH4 or the selective gentleness of NaBH4, NINGBO INNO PHARMCHEM CO.,LTD. is your premier source. We are dedicated to providing high-quality chemical intermediates, backed by expert technical support and a reliable supply chain. Contact us today to discuss your reagent needs and secure the best pricing for your next project. Trust us to be your dependable chemical supplier in China.