The Diels-Alder reaction, a cornerstone of organic synthesis, continues to evolve with the introduction of novel reaction media. Among these, ionic liquids (ILs) have emerged as particularly promising due to their unique properties such as low volatility, high thermal stability, and tunable solvation characteristics. This guide focuses on the application of N-hexylpyridinium bis(trifluoromethyl sulfonyl)imide (HPyr-TFSI) in facilitating and enhancing Diels-Alder reactions, offering insights for chemists and procurement managers looking to leverage these advanced materials.

Understanding N-Hexylpyridinium Bis(trifluoromethyl sulfonyl)Imide (HPyr-TFSI)

HPyr-TFSI, a pyridinium-based ionic liquid, possesses a molecular formula of C13H18F6N2O4S2 and a molecular weight of 444.42. Its CAS number is 460983-97-5. Key properties that make it attractive for chemical synthesis include its high purity (typically 99%), low melting point (0°C), and significant decomposition temperature (392°C). Its viscosity is around 80 cP, with a density of 1.39 g/cm³. Crucially for catalytic applications, it exhibits good solubility in many organic solvents, low halogen content (<1000 ppm), and low water content (<1000 ppm).

HPyr-TFSI as a Reaction Medium for Diels-Alder

Research has demonstrated HPyr-TFSI's efficacy as a reaction medium for Diels-Alder reactions. Studies comparing its performance with traditional solvents show that it can influence reaction rates and activation energies. When combined with Lewis acids such as Yb, Y, Mg, and Zn triflates and chlorides, HPyr-TFSI forms catalytic systems that can effectively mediate the cycloaddition. The recyclability of these catalytic systems, particularly those involving YCl3 and the ionic liquid, presents a significant advantage for sustainable chemical manufacturing. This makes HPyr-TFSI an excellent choice for those seeking efficient and greener synthesis routes. If you are looking to buy HPyr-TFSI for catalytic applications, understanding its stability and compatibility with various Lewis acids is key.

Advantages for Manufacturers and Researchers

The advantages of using HPyr-TFSI in Diels-Alder reactions and other syntheses are numerous:

  • Enhanced Reaction Rates: Ionic liquids can stabilize transition states, potentially leading to faster reactions.
  • Improved Selectivity: The unique solvation environment can influence stereoselectivity and regioselectivity.
  • Easier Product Separation: The non-volatile nature of ILs often simplifies product isolation.
  • Catalyst Recycling: Facilitates the recovery and reuse of expensive catalysts.
  • Environmentally Friendlier: Reduced solvent usage and potential for greener processes.

For businesses operating in organic synthesis, sourcing high-quality HPyr-TFSI is paramount. As a prominent manufacturer of ionic liquids in China, NINGBO INNO PHARMCHEM CO.,LTD. offers this critical reagent. We understand the importance of consistent supply and purity for your R&D and production needs. If you are seeking a reliable supplier for HPyr-TFSI, our extensive experience and commitment to quality assurance make us an ideal partner. Enquire about our HPyr-TFSI price to integrate this advanced ionic liquid into your workflow.

Key Considerations When Purchasing HPyr-TFSI

When sourcing HPyr-TFSI, consider the following:

  • Purity: Ensure the product meets your application's specific purity requirements (e.g., 99%).
  • Supplier Reliability: Choose a manufacturer with a proven track record in ionic liquid production and supply.
  • Technical Data: Request Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS) to confirm specifications.
  • Scale Availability: Confirm that the supplier can meet your volume requirements, from lab-scale to industrial production.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting the chemical industry with high-quality ionic liquids. We invite you to purchase N-hexylpyridinium bis(trifluoromethyl sulfonyl)imide from us to leverage its capabilities in your Diels-Alder reactions and other synthetic endeavors. Contact us today to discuss your specific requirements and to obtain a competitive quote for our premium HPyr-TFSI.