For any chemist engaged in the intricate world of organic synthesis, the ability to efficiently and selectively introduce amine functionalities is paramount. Among the array of reagents designed for this purpose, O-(Diphenylphosphinyl)hydroxylamine stands out as a remarkably versatile and effective tool. As a leading manufacturer and supplier of this crucial compound (CAS 72804-96-7) based in China, we are committed to providing researchers and procurement managers with the highest quality product to drive their innovations.

Electrophilic amination, the process of introducing an amino group (or a derivative thereof) as an electrophile onto a nucleophilic center, is a cornerstone of modern synthetic chemistry. O-(Diphenylphosphinyl)hydroxylamine excels in this domain, acting as a potent source of the electrophilic amino group. Its unique structure, featuring a diphenylphosphinyl moiety attached to the oxygen of hydroxylamine, imbues it with distinct reactivity that allows for precise control over reaction outcomes.

One of the primary applications of this reagent is in the N-amination of various nitrogen-containing heterocycles and amines. For instance, it readily reacts with the NH groups found in important structures like imidazoles, xanthines, and indoles. This capability is invaluable for researchers developing pharmaceuticals or agrochemicals, where subtle modifications to heterocyclic cores can dramatically alter biological activity. By choosing to buy from a reliable manufacturer, you ensure consistent purity and performance for these sensitive reactions.

Furthermore, O-(Diphenylphosphinyl)hydroxylamine has demonstrated exceptional utility in the direct N-amination of primary and secondary amines. Often, this process begins with the deprotonation of the amine substrate, typically using a strong base like sodium hydride, followed by the addition of our high-quality reagent. The resulting product is a new, more complex amine, enabling the construction of diverse molecular architectures. The advantage of sourcing from a dedicated supplier like us lies in the assurance of receiving a product that meets stringent quality standards, minimizing batch-to-batch variability.

Beyond simple amination, this organophosphorus compound also plays a significant role in enabling novel synthetic transformations, such as nitrogen deletion reactions. This methodology allows for the strategic removal of a nitrogen atom from secondary amines, paving the way for efficient C(sp3)–C(sp3) bond formation. Such advanced reactions are critical for the synthesis of complex natural products or the creation of novel molecular scaffolds in drug discovery programs. When considering the purchase of such a specialized reagent, inquiring about the price from an established manufacturer in China is a wise procurement strategy.

The physical characteristics of O-(Diphenylphosphinyl)hydroxylamine further enhance its appeal. It is typically supplied as an off-white powder, possessing good bench stability when stored correctly. Its molecular formula, C12H12NO2P, and molecular weight of 233.2 g/mol are well-defined, ensuring ease of handling and stoichiometric calculations. For bulk purchases or to discuss specific application needs, contacting our sales team for a competitive quote is the first step towards securing this indispensable reagent for your laboratory or production facility.