For organic chemists, the selection of appropriate building blocks is fundamental to the success of any synthetic endeavor. 2,3-Difluorobenzyl bromide (CAS: 113211-94-2) is a prime example of a functionalized intermediate that offers significant advantages in constructing complex molecules, particularly those requiring fluorination. As a supplier of high-quality chemical intermediates, we understand the intricate needs of synthetic chemists and provide materials that meet exacting standards.

The Chemical Profile of 2,3-Difluorobenzyl Bromide

As a benzyl bromide derivative, 2,3-Difluorobenzyl bromide possesses a highly reactive benzylic bromide moiety. This makes it an excellent electrophile for a variety of nucleophilic substitution reactions (SN1 and SN2). The presence of two fluorine atoms at the ortho and meta positions on the phenyl ring influences the electronic distribution of the molecule. This can affect the reactivity of the benzylic position and introduce specific electronic and lipophilic characteristics into the final product. The typical appearance is a colorless to pale yellow liquid, with a purity often specified as ≥99.0% by GC.

Key Synthetic Transformations and Applications

The primary utility of 2,3-Difluorobenzyl bromide lies in its ability to introduce the 2,3-difluorobenzyl group into target molecules. This is achieved through reactions with various nucleophiles:

  • Alkylation of Amines and Alcohols: Reaction with primary or secondary amines yields tertiary or quaternary ammonium salts, respectively. Similarly, reaction with alcohols or phenols in the presence of a base can form ethers. These reactions are foundational in building complex organic scaffolds.
  • Formation of Esters and Thioethers: Carboxylic acids and thiols can be alkylated to form the corresponding esters and thioethers, respectively, further expanding the synthetic utility.
  • Carbon-Carbon Bond Formation: Through reactions with stabilized carbanions (e.g., from malonates or beta-keto esters), new carbon-carbon bonds can be forged, enabling the extension of carbon chains.

These transformations are critical in the synthesis of active pharmaceutical ingredients (APIs), agrochemical compounds, and other fine chemicals where the 2,3-difluorobenzyl moiety is a desired structural component. Many researchers choose to buy this compound to access novel fluorinated derivatives that may exhibit improved pharmacological or biological properties.

Tips for Working with 2,3-Difluorobenzyl Bromide

When working with this intermediate, it is important to handle it with care. Benzyl bromides are lachrymatory and skin irritants. Always use appropriate personal protective equipment (PPE) and work in a well-ventilated fume hood. Storage conditions typically recommend keeping it in a cool, dry place, often refrigerated (2-8 °C), to maintain its stability and purity.

As a dedicated manufacturer, we ensure that the 2,3-Difluorobenzyl bromide we supply meets the highest purity standards, crucial for sensitive research. If you are looking to purchase this versatile intermediate for your next synthesis project, consider our reliable supply and competitive pricing. We are here to support your chemical endeavors.