The Mitsunobu reaction stands as a cornerstone of modern organic synthesis, celebrated for its ability to achieve stereochemical inversion of secondary alcohols and facilitate a variety of functional group interconversions. At its heart lies a set of key reagents, among which 1,1'-(Azodicarbonyl)dipiperidine (ADDP), also known by its CAS number 10465-81-3, plays a pivotal role. For procurement managers and research scientists in the B2B chemical sector, understanding the selection and application of high-quality ADDP from a trusted manufacturer is crucial for successful project outcomes.

Why is ADDP Essential for the Mitsunobu Reaction?

The Mitsunobu reaction typically involves an alcohol, a nucleophile (often a weak acid), a phosphine (commonly triphenylphosphine), and an azodicarboxylate, such as ADDP. This combination enables the substitution of the alcohol's hydroxyl group with the nucleophile, proceeding with inversion of configuration at the stereogenic center. ADDP, with its pale yellow to yellow solid appearance, offers a convenient and effective azodicarboxylate source. Its consistent purity, often exceeding 98%, directly impacts the reaction's efficiency and the yield of the desired product. When you aim to buy ADDP for your R&D or manufacturing, prioritizing purity ensures predictable and reproducible results, a key factor for any supplier-buyer relationship.

Choosing the Right ADDP Supplier: A Strategic Decision

For B2B clients, the choice of an ADDP supplier is more than just a transactional decision; it's a strategic one that can influence project timelines, product quality, and overall cost-effectiveness. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer and supplier, understands these critical needs. We offer:

  • Uncompromised Purity: Our ADDP is manufactured to stringent quality standards, ensuring it meets the high purity requirements for advanced organic synthesis, crucial for pharmaceutical intermediates and fine chemical production.
  • Competitive Pricing: By purchasing directly from a manufacturer in China, you benefit from competitive pricing without compromising on quality. This makes sourcing ADDP more economical for your bulk requirements.
  • Reliable Supply: We maintain robust production capabilities to ensure a consistent and dependable supply of ADDP, mitigating risks of project delays due to stockouts. Our goal is to be your go-to supplier for this vital reagent.
  • Technical Support: While we focus on delivering quality products, we also aim to support our clients with the necessary information to effectively use our reagents.

Applications Beyond Standard Mitsunobu Inversions

While the inversion of secondary alcohols is a hallmark application, ADDP's utility extends further. It is employed in the synthesis of esters, ethers, and even in the preparation of complex heterocyclic compounds. Researchers in agrochemicals and materials science also leverage ADDP for specific transformations. When considering your next synthetic challenge, think about where ADDP can streamline your process and enhance your product development.

For procurement managers and research scientists looking to buy high-quality 1,1'-(Azodicarbonyl)dipiperidine, partnering with NINGBO INNO PHARMCHEM CO.,LTD. ensures access to a reliable source of this essential synthetic reagent. Contact us today for pricing and to discuss your specific needs.