The synthesis of 2-Bromo-4-Methoxy-1-Methyl-benzene (CAS: 36942-56-0) is a critical step for many in the chemical industry, particularly those involved in creating advanced organic compounds. This aryl bromide serves as a valuable intermediate, and understanding its production is key for researchers and manufacturers alike. We, at NINGBO INNO PHARMCHEM CO.,LTD., specialize in providing high-quality chemical intermediates, and this particular compound is no exception. Our expertise ensures that we can guide you through the intricacies of its synthesis.

The primary synthesis route for 2-Bromo-4-Methoxy-1-Methyl-benzene often begins with readily available precursors. A common method involves the bromination of a suitably substituted aromatic ring. For instance, starting materials like 4-methoxy-1-methyl-benzene or its derivatives can be employed. The reaction typically requires a brominating agent, such as N-bromosuccinimide (NBS) or elemental bromine, in the presence of a catalyst or under specific reaction conditions to ensure regioselectivity. The presence of the methoxy group and the methyl group on the benzene ring influences the position of bromination, directing the bromine atom to the desired ortho position relative to the methoxy group.

One widely documented synthesis involves using 5-Methoxy-2-methylaniline as a starting material. This precursor is reacted in a mixed solution of hydrobromic acid and ethanol. The mixture is cooled, and an aqueous solution of sodium nitrite is slowly added. This process leads to diazotization. Following this, the diazonium salt is transferred to a preheated solution of cuprous bromide in hydrobromic acid, and the mixture is refluxed. This Sandmeyer-type reaction introduces the bromine atom into the molecule. After the reaction is complete, the product is extracted, washed, dried, and purified, often through column chromatography. This detailed synthesis ensures a high yield and purity of the final product, making it ready for further use.

For those looking to buy 2-Bromo-4-Methoxy-1-Methyl-benzene, understanding the synthesis helps in appreciating the quality and consistency you can expect. As a leading supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing chemicals that meet stringent standards. Whether you are conducting academic research or scaling up production, our reliable supply chain and technical support are designed to meet your needs. We offer competitive prices and free samples to qualified buyers, ensuring you can confidently integrate our products into your workflow.

Exploring the 2-Bromo-4-Methoxy-1-Methyl-benzene synthesis options allows for optimization of existing processes or development of new ones. The specific reaction conditions, such as temperature control and reaction time, are crucial for maximizing yield and minimizing side products. By partnering with NINGBO INNO PHARMCHEM CO.,LTD., you gain access to a wealth of knowledge and a consistent supply of this essential chemical reagent. We are dedicated to supporting your chemical endeavors with our superior products and services.