For many in the B2B chemical and pharmaceutical sectors, understanding the fundamental properties and applications of key intermediates is crucial. N-(4-Nitrophenyl)maleimide (CAS: 4338-06-1) is one such compound, serving as a versatile building block in a myriad of synthetic pathways. This primer is designed for procurement managers, R&D scientists, and formulation chemists who need a concise overview of this important chemical.

Chemical Identity and Properties

N-(4-Nitrophenyl)maleimide, with the molecular formula C10H6N2O4 and a molecular weight of 218.166, is characterized by its distinctive structure. It features a maleimide ring, known for its high reactivity in cycloaddition and conjugate addition reactions, linked to a 4-nitrophenyl group. This combination provides specific chemical characteristics, including a melting point typically around 170°C. As a yellow crystalline powder, it is generally stable under standard laboratory conditions. When sourcing this material, look for suppliers who provide a minimum purity of 95% to ensure suitability for demanding synthetic applications.

Primary Uses in Organic Synthesis

The primary utility of N-(4-Nitrophenyl)maleimide lies in its role as a reactive intermediate in organic synthesis. The electron-deficient double bond in the maleimide ring makes it an excellent dienophile in Diels-Alder reactions and a potent Michael acceptor for nucleophiles, particularly primary amines. This reactivity is exploited in the synthesis of complex organic molecules, including heterocycles, polymers, and potential pharmaceutical drug candidates. Researchers often rely on such intermediates to construct novel molecular scaffolds. If you are looking to buy this compound for your research, consider its reactivity profile for your specific synthetic strategy.

Where to Buy and Supplier Considerations

When seeking to purchase N-(4-Nitrophenyl)maleimide, it is essential to identify reliable suppliers. Direct manufacturers, particularly those based in China, often offer competitive price points and can guarantee product quality and consistency. These suppliers are typically equipped to handle both small-scale R&D needs and larger industrial quantities. Beyond standard catalog offerings, many manufacturers provide custom synthesis services, which can be invaluable if you require specific derivatives or higher purity grades than typically available. When inquiring, always ask for technical data sheets and a Certificate of Analysis (CoA) to verify the product's specifications.

Importance of Quality Control and Customization

The quality of any chemical intermediate directly impacts the outcome of subsequent reactions and the final product's efficacy or performance. Therefore, choosing a supplier that adheres to stringent quality control measures is non-negotiable. For N-(4-Nitrophenyl)maleimide, this means ensuring the stated purity is met and that batch-to-batch consistency is maintained. For specialized projects, the ability of a manufacturer to perform custom synthesis can be a critical differentiator. This service allows R&D scientists to obtain precisely engineered molecules, pushing the boundaries of chemical discovery and product development. For those needing this intermediate, exploring the custom synthesis options from a trusted Chinese provider can be a strategic advantage.

Conclusion

N-(4-Nitrophenyl)maleimide is a valuable tool in the synthetic chemist's arsenal. Its inherent reactivity and the ability to source it from reliable manufacturers with competitive pricing make it an attractive intermediate for a wide range of applications. By understanding its properties and working with reputable suppliers, researchers and procurement specialists can effectively leverage this compound for their projects.