The synthesis of 5-Bromo-2-iodophenol (CAS: 858855-11-5) is a critical process for chemists requiring this valuable organic building block. Understanding the nuances of the 5-bromo-2-iodophenol synthesis route is key to achieving high purity and yield. This article provides an overview of a common synthetic pathway, highlighting the reagents and conditions necessary for its successful preparation.

A typical 5-bromo-2-iodophenol synthesis begins with 2-amino-5-bromophenol. The process involves several steps, including diazotization followed by iodination. Boron trifluoride diethyl etherate and tert-butyl nitrite are often employed in the initial stages. Subsequent treatment with potassium iodide and iodine in acetonitrile leads to the desired product. This method, while effective, requires precise control of temperature and reaction times to optimize the outcome and minimize unwanted by-products.

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The resulting 5-Bromo-2-iodophenol is a solid compound, typically off-white to light yellow in color. Its physical and chemical properties, including its melting point and density, are crucial for its application in various organic transformations. The 5-bromo-2-iodophenol chemical intermediate is highly valued for its role in the synthesis of more complex molecules, particularly in the pharmaceutical industry. When considering the price to buy 5-bromo-2-iodophenol, it's important to factor in the quality and purity provided by reputable manufacturers.

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