Pentafluorobenzenesulfonyl Chloride (CAS 832-53-1) is a compound of significant interest in both academic research and industrial applications, particularly in organic synthesis and analytical chemistry. Understanding its properties and handling requirements is crucial for safe and effective laboratory use. As a leading chemical supplier in China, we provide high-purity materials and essential technical information for our customers.

Key Physical and Chemical Properties

Pentafluorobenzenesulfonyl Chloride is characterized by its colorless liquid appearance. Its boiling point is approximately 210.5 ± 35.0 °C at 760 mmHg, and it has a density of around 1.8 g/cm³. With a molecular formula of C6ClF5O2S and a molecular weight of 266.57 g/mol, its structure comprises a highly fluorinated aromatic ring connected to a sulfonyl chloride group. This sulfonyl chloride group makes it highly reactive, especially towards nucleophiles like water, alcohols, and amines. It is known to be moisture-sensitive, necessitating storage under anhydrous conditions to prevent hydrolysis into pentafluorobenzenesulfonic acid.

Applications in Research and Development

The compound finds extensive use as a derivatizing agent to improve the detectability and volatility of various analytes in techniques such as Gas Chromatography (GC) and Liquid Chromatography (LC). The introduction of the pentafluorobenzenesulfonyl group enhances signal intensity, particularly in electron-capture detection (ECD). Furthermore, it serves as a valuable reagent in organic synthesis for perfluorophenylation reactions, allowing chemists to introduce specific fluorinated moieties into target molecules, which can modify properties like thermal stability and electronic characteristics.

Safe Handling and Storage Recommendations

Given its reactive and corrosive nature, proper handling of Pentafluorobenzenesulfonyl Chloride is paramount. It is classified as a skin and eye irritant and is toxic if inhaled or ingested. Always use appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably a fume hood, to avoid inhalation of vapors. Due to its moisture sensitivity, containers should be tightly sealed, and the compound stored in a cool, dry place away from incompatible substances such as water, bases, and strong oxidizing agents.

Sourcing High-Quality Pentafluorobenzenesulfonyl Chloride

For researchers and procurement professionals seeking to buy Pentafluorobenzenesulfonyl Chloride, it is vital to partner with a reliable supplier. Our company, a prominent manufacturer in China, offers this compound with a guaranteed minimum purity of 99%. We ensure that our products meet rigorous quality standards, making them suitable for demanding applications in laboratories worldwide. We provide detailed product specifications and are available to answer inquiries regarding pricing, bulk orders, and sample requests. Ensuring you have a dependable source for this key intermediate can significantly streamline your research and development processes.