The field of analytical chemistry, particularly mass spectrometry (MS), often requires precise derivatization techniques to enhance the detection and quantification of analytes. Pivalic anhydride, also known as Trimethylacetic anhydride (CAS 1538-75-6), has gained significant traction as a powerful derivatization reagent for MS-based workflows, especially in complex sample analysis.

NINGBO INNO PHARMCHEM CO.,LTD., a leading supplier of fine chemicals in China, provides high-purity Trimethylacetic anhydride suitable for these advanced analytical applications. In MS analysis, derivatization aims to improve volatility, ionization efficiency, and chromatographic separation of target molecules. Pivalic anhydride excels in acylating primary amines, such as lysine side chains and peptide N-termini, which is crucial for suppressing charge-induced peptide heterogeneity and enabling accurate MS1-level quantification.

The synthesis of Trimethylacetic anhydride ensures its consistent performance as a derivatization agent. For instance, in proteomic studies involving histone modifications, the use of pivalic anhydride can lead to enhanced chromatographic resolution of derivatized peptides. This improvement facilitates the extraction of quantitative signals directly from MS1 data, a significant advancement over conventional methods. When researchers look to buy Trimethylacetic anhydride for such sensitive analytical tasks, the purity and reliability offered by NINGBO INNO PHARMCHEM CO.,LTD. are invaluable.

The chemical intermediate nature of Trimethylacetic anhydride allows it to be a versatile tool for researchers. Its ability to react quickly and efficiently under specific conditions, such as microwave irradiation, further shortens analysis times while maintaining high derivatization yields. This makes it an excellent choice for laboratories aiming to optimize their MS-based quantitative strategies and obtain high-resolution, quantitative data essential for various research areas, including epigenetics and chromatin studies. NINGBO INNO PHARMCHEM CO.,LTD. is your reliable source for this critical analytical reagent.