For professionals in the chemical industry, particularly those involved in organic synthesis, research and development, and pharmaceutical manufacturing, the selection and procurement of high-quality reagents are critical decisions. 2-(Trimethylsilyl)ethoxymethyl chloride, often abbreviated as SEM-Cl (CAS 76513-69-4), is a prominent reagent known for its efficacy in protecting hydroxyl functionalities. This article serves as a guide for procurement managers and R&D scientists looking to understand and source this vital chemical intermediate.

As a leading manufacturer and supplier of specialty chemicals, we recognize the importance of providing clear, actionable information to our potential clients. Understanding the product’s properties, applications, and how to best acquire it is paramount.

Understanding 2-(Trimethylsilyl)ethoxymethyl Chloride (SEM-Cl)

SEM-Cl is primarily employed in organic synthesis as a means to introduce the SEM protecting group onto alcohols. The resulting SEM ethers offer excellent stability under a variety of reaction conditions, including exposure to organometallic reagents, strong bases, and many oxidizing or reducing agents. This broad compatibility makes it an ideal choice for multi-step syntheses where functional group integrity is essential. The ability to selectively cleave the SEM group using mild acidic treatments or fluoride sources, such as TBAF, adds to its versatility and strategic value in complex synthetic pathways.

When considering where to buy this compound, its chemical formula (C6H15ClOSi) and appearance (typically a light yellow liquid) are standard specifications. However, the crucial aspect for any buyer is the purity and reliability of the supply chain.

Why Partner with a China Manufacturer for SEM-Cl?

The global chemical supply chain offers various sourcing options, but partnering with a reputable China manufacturer for intermediates like 2-(Trimethylsilyl)ethoxymethyl chloride can offer significant advantages. We, as a dedicated manufacturer, ensure rigorous quality control, guaranteeing a high purity of ≥99.0% for our SEM-Cl. This consistency is vital for reproducible results in your laboratory or production facility.

Furthermore, direct sourcing from a manufacturer often translates into competitive factory pricing. For procurement managers looking to optimize budgets without compromising on quality, engaging with a China-based supplier like us provides a strategic advantage. We cater to both small-scale R&D needs and larger industrial requirements.

Key Considerations for Buyers

When you decide to buy CAS 76513-69-4, consider the specific requirements of your synthesis. The SEM protection strategy is particularly valuable in the production of pharmaceutical intermediates and other fine chemicals where selective manipulation of hydroxyl groups is necessary. Its stability profile ensures that other parts of a complex molecule can be modified without affecting the protected hydroxyl.

We invite you to contact us to request a quotation for 2-(Trimethylsilyl)ethoxymethyl chloride. Our team is ready to provide you with detailed product information, discuss your specific needs, and offer tailored solutions. Secure your supply of this essential organic synthesis reagent from a trusted and experienced manufacturer.