Understanding the Properties and Applications of 2-Trifluoromethyl-5-bromopyridine
2-Trifluoromethyl-5-bromopyridine (CAS 436799-32-5) is a fine chemical intermediate that plays a significant role in various scientific and industrial applications. Understanding its physical and chemical properties is key to appreciating its utility as a versatile building block in organic synthesis, particularly within the pharmaceutical and agrochemical sectors.
Physically, 2-Trifluoromethyl-5-bromopyridine typically presents as a white to off-white crystal powder. It possesses a moderate melting point, usually in the range of 41-45°C, and a boiling point of approximately 179.1°C at 760 mmHg. Its density is around 1.707 g/cm³. While soluble in many common organic solvents, it exhibits low solubility in water. These characteristics are important for its handling, purification, and use in reaction media.
Chemically, the compound is characterized by its pyridine ring substituted with a highly electronegative trifluoromethyl group at the 2-position and a bromine atom at the 5-position. This arrangement confers unique reactivity. The bromine atom is a good leaving group, readily participating in nucleophilic substitution reactions and metal-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings. The trifluoromethyl group, besides influencing electronic properties, can also impact steric interactions and metabolic stability in synthesized molecules. This dual functionality makes 2-Trifluoromethyl-5-bromopyridine an ideal intermediate for creating complex molecular architectures.
The primary applications of 2-Trifluoromethyl-5-bromopyridine lie in its role as an intermediate. In the pharmaceutical industry, it is used to synthesize a wide range of active pharmaceutical ingredients (APIs). Its structural features can be incorporated into drug candidates designed to treat various diseases, from infectious diseases to metabolic disorders. The ability to purchase 2-Trifluoromethyl-5-bromopyridine with high purity ensures that these complex syntheses proceed efficiently and yield products of the required quality.
In the agrochemical industry, this compound serves as a precursor for the development of new pesticides, herbicides, and fungicides. The trifluoromethyl moiety is often associated with increased bioactivity and stability in agrochemical products. Researchers often use 2-Trifluoromethyl-5-bromopyridine to create compounds that offer enhanced pest control and crop protection.
For those involved in organic synthesis, its utility extends to the creation of advanced materials and specialty chemicals. Its predictable reactivity allows chemists to design efficient synthetic routes for novel compounds. Understanding the properties of 2-Trifluoromethyl-5-bromopyridine is essential for anyone looking to leverage its potential in their research or manufacturing processes. When sourcing this chemical, it's vital to partner with reliable manufacturers who can provide detailed product information and ensure consistent quality.
Physically, 2-Trifluoromethyl-5-bromopyridine typically presents as a white to off-white crystal powder. It possesses a moderate melting point, usually in the range of 41-45°C, and a boiling point of approximately 179.1°C at 760 mmHg. Its density is around 1.707 g/cm³. While soluble in many common organic solvents, it exhibits low solubility in water. These characteristics are important for its handling, purification, and use in reaction media.
Chemically, the compound is characterized by its pyridine ring substituted with a highly electronegative trifluoromethyl group at the 2-position and a bromine atom at the 5-position. This arrangement confers unique reactivity. The bromine atom is a good leaving group, readily participating in nucleophilic substitution reactions and metal-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings. The trifluoromethyl group, besides influencing electronic properties, can also impact steric interactions and metabolic stability in synthesized molecules. This dual functionality makes 2-Trifluoromethyl-5-bromopyridine an ideal intermediate for creating complex molecular architectures.
The primary applications of 2-Trifluoromethyl-5-bromopyridine lie in its role as an intermediate. In the pharmaceutical industry, it is used to synthesize a wide range of active pharmaceutical ingredients (APIs). Its structural features can be incorporated into drug candidates designed to treat various diseases, from infectious diseases to metabolic disorders. The ability to purchase 2-Trifluoromethyl-5-bromopyridine with high purity ensures that these complex syntheses proceed efficiently and yield products of the required quality.
In the agrochemical industry, this compound serves as a precursor for the development of new pesticides, herbicides, and fungicides. The trifluoromethyl moiety is often associated with increased bioactivity and stability in agrochemical products. Researchers often use 2-Trifluoromethyl-5-bromopyridine to create compounds that offer enhanced pest control and crop protection.
For those involved in organic synthesis, its utility extends to the creation of advanced materials and specialty chemicals. Its predictable reactivity allows chemists to design efficient synthetic routes for novel compounds. Understanding the properties of 2-Trifluoromethyl-5-bromopyridine is essential for anyone looking to leverage its potential in their research or manufacturing processes. When sourcing this chemical, it's vital to partner with reliable manufacturers who can provide detailed product information and ensure consistent quality.
Perspectives & Insights
Alpha Spark Labs
“Physically, 2-Trifluoromethyl-5-bromopyridine typically presents as a white to off-white crystal powder.”
Future Pioneer 88
“It possesses a moderate melting point, usually in the range of 41-45°C, and a boiling point of approximately 179.”
Core Explorer Pro
“While soluble in many common organic solvents, it exhibits low solubility in water.”