Understanding the Properties and Applications of Vinylboronic Acid Pinacol Ester
Vinylboronic Acid Pinacol Ester (VBPE), identified by the CAS number 75927-49-0, is a significant fine chemical intermediate extensively utilized in contemporary chemical research and development. Its chemical formula is C8H15BO2, with a molecular weight of 154.02 g/mol. Typically, VBPE is supplied with a high purity, commonly around 98%, ensuring reliable performance in delicate synthetic procedures. Physically, it is described as a clear, colorless to amber liquid, although it is known to be sensitive to light and air, and is also flammable.
The stability and reactivity profile of VBPE are largely attributed to the pinacol ester group, which protects the boronic acid functionality while still allowing for efficient participation in key synthetic transformations. This makes it a preferred reagent over more reactive boronic acids in many applications.
One of the most prominent applications of VBPE is its central role in Suzuki-Miyaura cross-coupling reactions. This palladium-catalyzed process is a cornerstone of modern organic synthesis, enabling the formation of carbon-carbon bonds between organoboron compounds and organic halides or triflates. VBPE serves as an excellent vinylating agent in these reactions, allowing for the introduction of vinyl groups into a diverse range of organic molecules. This is particularly important in the synthesis of complex natural products, pharmaceuticals, and advanced materials.
In the pharmaceutical industry, VBPE functions as a vital building block and intermediate for the synthesis of Active Pharmaceutical Ingredients (APIs). Its specific structure and reactivity allow chemists to construct intricate molecular frameworks essential for drug efficacy. The ability to precisely introduce vinyl groups is a key advantage in designing and synthesizing novel therapeutic compounds.
Beyond its direct use in coupling reactions, VBPE is also explored in other areas of chemical research. Its potential applications are being investigated in fields such as material science and the development of new catalytic systems. The controlled introduction of the vinyl moiety can lead to polymers with tailored properties or novel intermediates for further synthetic elaboration.
For researchers and industrial chemists, understanding the handling and storage requirements of VBPE is crucial. Due to its flammability and sensitivity, it is often stored under an inert atmosphere and protected from light. Reputable suppliers, frequently located in China, provide detailed technical data sheets and safety information to ensure proper usage. These suppliers are vital for maintaining a consistent supply of high-purity VBPE for ongoing research and production.
In summary, Vinylboronic Acid Pinacol Ester is a highly versatile and important chemical intermediate. Its properties make it an invaluable tool for organic synthesis, especially in Suzuki-Miyaura coupling reactions and pharmaceutical intermediate production, solidifying its position as a key reagent in chemical research.
The stability and reactivity profile of VBPE are largely attributed to the pinacol ester group, which protects the boronic acid functionality while still allowing for efficient participation in key synthetic transformations. This makes it a preferred reagent over more reactive boronic acids in many applications.
One of the most prominent applications of VBPE is its central role in Suzuki-Miyaura cross-coupling reactions. This palladium-catalyzed process is a cornerstone of modern organic synthesis, enabling the formation of carbon-carbon bonds between organoboron compounds and organic halides or triflates. VBPE serves as an excellent vinylating agent in these reactions, allowing for the introduction of vinyl groups into a diverse range of organic molecules. This is particularly important in the synthesis of complex natural products, pharmaceuticals, and advanced materials.
In the pharmaceutical industry, VBPE functions as a vital building block and intermediate for the synthesis of Active Pharmaceutical Ingredients (APIs). Its specific structure and reactivity allow chemists to construct intricate molecular frameworks essential for drug efficacy. The ability to precisely introduce vinyl groups is a key advantage in designing and synthesizing novel therapeutic compounds.
Beyond its direct use in coupling reactions, VBPE is also explored in other areas of chemical research. Its potential applications are being investigated in fields such as material science and the development of new catalytic systems. The controlled introduction of the vinyl moiety can lead to polymers with tailored properties or novel intermediates for further synthetic elaboration.
For researchers and industrial chemists, understanding the handling and storage requirements of VBPE is crucial. Due to its flammability and sensitivity, it is often stored under an inert atmosphere and protected from light. Reputable suppliers, frequently located in China, provide detailed technical data sheets and safety information to ensure proper usage. These suppliers are vital for maintaining a consistent supply of high-purity VBPE for ongoing research and production.
In summary, Vinylboronic Acid Pinacol Ester is a highly versatile and important chemical intermediate. Its properties make it an invaluable tool for organic synthesis, especially in Suzuki-Miyaura coupling reactions and pharmaceutical intermediate production, solidifying its position as a key reagent in chemical research.
Perspectives & Insights
Core Pioneer 24
“In summary, Vinylboronic Acid Pinacol Ester is a highly versatile and important chemical intermediate.”
Silicon Explorer X
“Its properties make it an invaluable tool for organic synthesis, especially in Suzuki-Miyaura coupling reactions and pharmaceutical intermediate production, solidifying its position as a key reagent in chemical research.”
Quantum Catalyst AI
“Vinylboronic Acid Pinacol Ester (VBPE), identified by the CAS number 75927-49-0, is a significant fine chemical intermediate extensively utilized in contemporary chemical research and development.”